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Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 3

Washington University School of Medicine · with National Institute of Mental Health (NIMH), University of Minnesota · NCT07900893

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–59 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
10000
US sites recruiting
2
Study start
December 1, 2026
Record last updated
October 28, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

In Study 3, all tasks and models from Aim 1 will be evaluated in a large community sample of online participants recruited through Prolific.

Aim 3 will establish 1) requirements for testing computational algorithms in population-based samples, 2) whether task length is optimal, and 3) whether computational parameters help predict psychopathology (hallucinations and delusions in particular) in the general population, and how these predictors may be impacted by demographic variables, such as race, ethnicity, gender, age and other social determinants of health.

Participant demographics will be matched to the U.S. Census 2023 American Community Survey (ACS) data release (updated as available). MPI MacDonald has successfully recruited large online samples for over a decade.

Specifically, researchers will recruit two samples of n=2,000 to preregister hypotheses and then n=3,000 to independently confirm those hypotheses. Multiple methods will affirm the highest quality human self-report and behavioral data for online samples.

Researchers use Prolific, which is known for high quality research participation, maintaining low levels of bots through strategies such as requiring a photo ID and a waiting period. Second, inclusion criteria will require an approval rating of 90-100% from previous researchers. Participants will complete three sessions, each limited to \~60 min to avoid burnout.

Being studied: Motion Perception Task; Sine Wave Speech Task; Volatility Task; Choice Probabilistic Reversal Task; Kamin Blocking Task; Minnesota Trust Game; Dynamic Trust Game

Conditions: Schizophrenia / Schizoaffective Disorder; SCHIZOPHRENIA 1 (Disorder); Healthy Adult

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Residents of the U.S.
  • between 18-59 years of age

Exclusion Criteria

  • Resides outside of U.S.
  • under 18 or over 59 years of age

Recruiting US locations

  • University of Minnesota

    Minneapolis, MN 55455

    Site contact: Angus MacDonald III, PhD · 612-624-3813 · angus@umn.edu

  • Washington University

    St Louis, MO 63130

    Site contact: Deanna Barch, PhD · 314-935-8729 · dbarch@wustl.edu

Study contacts (from the official record)

  • Deanna Barch, PhD · 314-935-8729 · dbarch@wustl.edu
All mental health studies in Minnesota →
Cognitive Neurocomputational Task Reliability and Clinical… (NCT07900893) | Bored Studies