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RecruitingAccepts healthy volunteersPhase 2

Convergent Mechanisms Underlying Reprometabolic Syndrome in Women

University of Colorado, Denver · with Colorado Clinical & Translational Sciences Institute · NCT06686537

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–38 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
20
US sites recruiting
2
Study start
February 25, 2025
Record last updated
July 21, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Dr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus. This will be shown in diminished pituitary sensitivity to gonadorelin releasing hormone with a reduced estradiol induced luteinizing hormone surge in obese women.

Being studied: Estradiol Patches

Conditions: Infertility, Female; Obesity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age 18-38
  • Regular menstrual cycles every 25-35 days
  • No use of reproductive hormones within the past 3 months
  • No use of medications interacting with reproductive hormones
  • Agreement to use reliable barrier contraception or to abstain from intercourse for the duration of the study
  • Normal thyroid stimulating hormone, prolactin and lipid profiles
  • No more than 4 hours of moderate to vigorous intensity exercise per week
  • No history of chronic disease impacting reproductive hormones
  • No contraindications to administration of estradiol
  • No history of estrogen dependent cancer
  • Negative pregnancy test

Exclusion Criteria

  • Has diabetes
  • Is a smoker
  • History of venous thromboembolism or known thrombophilia

Recruiting US locations

  • University of Colorado School of Medicine

    Aurora, CO 80045

  • University of Colorado-School of Medicine

    Aurora, CO 80045

    Site contact: Asma Giornazi, MS · 303-724-5276 · Asma.Giornazi@cuanschutz.edu

Study contacts (from the official record)

  • Carrie Hsu · 303-724-5276 · Carire.Hsu@cuanschutz.edu
  • Asma Giornazi · asma.giornazi@cuanschutz.edu
All weight loss studies in Colorado →
Convergent Mechanisms Underlying Reprometabolic Syndrome in Women (NCT06686537) | Bored Studies