Skip to content
Bored Studies
RecruitingAccepts healthy volunteersPhase 4

CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera

University of Maryland, Baltimore · NCT03705585

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
240
US sites recruiting
1
Study start
November 5, 2018
Record last updated
September 4, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is an open-label, non-randomized study. The purpose of this study is to better understand how vaccines against typhoid fever and cholera affect the normal immune system and bacteria in the intestine. Patients having standard-of-care endoscopies (colonoscopy and/or esophagogastroduodenoscopy (EGD)) will be divided into 3 groups:

Group 1: Vivotif typhoid vaccination and/or Vaxchora cholera vaccination then endoscopy Group 2: Endoscopy, then Vivotif typhoid vaccination and/or Vaxchora cholera vaccination, then follow-up endoscopy Group 3: Endoscopy without vaccination.

Both vaccines used in this study are licensed by the Food and Drug Administration (FDA) for travelers to developing countries. Volunteers will be asked to donate tissue, blood, saliva and stool samples for studying how the body responds to the typhoid and/or cholera vaccine.

Being studied: Vivotif Typhoid Oral Vaccine; Vaxchora

Conditions: Typhoid and/or Cholera Vaccination

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 1. Age 18 years and older
  • 2. Already scheduled to undergo an EGD or colonoscopy for screening, surveillance, or a medically-indicated work-up at the University of Maryland Medical Center (main campus or Midtown)
  • 3. Able to provide written informed consent prior to initiation of any study procedures
  • 4. Healthy, as defined by considered fit to undergo outpatient elective EGD/colonoscopy by the evaluating health care provider

Exclusion Criteria

  • 1. Pregnancy or nursing mother
  • 2. Known coagulopathy or bleeding disorder preventing mucosal biopsy
  • 3. History of Crohn's disease or ulcerative colitis
  • 4. For Subjects undergoing lower endoscopy (colonoscopy) only: Surgical removal of the ileocecal valve or any part of the small or large intestine (non-complicated appendectomy will be considered eligible)
  • 5. Allergic reaction to oral typhoid or cholera vaccine in the past
  • 6. Immunosuppression from illness or treatment, including
  • immune-deficiency disorders such as Human Immunodeficiency Virus (HIV) or Acquired Immunodeficiency Syndrome (AIDS)
  • leukemia, lymphoma, or cancers (localized non-melanoma skin cancers which are deemed inactive should be considered eligible)
  • 7. Receipt of any other vaccine two weeks prior to receipt of Ty21a or CVD 103-HgR
  • 8. Positive urine pregnancy test (HCG) prior to colonoscopy or vaccination

Recruiting US locations

  • University of Maryland, Baltimore, Center for Vaccine Development and Global Health

    Baltimore, MD 21201

    Site contact: Susan Holian, RN · susan.holian@som.umaryland.edu

Study contacts (from the official record)

  • Rosary Zara Necesario, RN · 410-706-6156 · rnecesario@som.umaryland.edu
All vaccine studies in Maryland →
CVD 38000: Study of Responses to Vaccination With Typhoid and/or… (NCT03705585) | Bored Studies