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RecruitingAccepts healthy volunteers

Daily Upgrade Trial

University of North Carolina, Chapel Hill · with Sportiv, Inc. · NCT07792603

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 25–45 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
44
US sites recruiting
1
Study start
August 31, 2026
Record last updated
September 3, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study evaluates the acute and chronic effects of an essential amino acid supplement (Daily Upgrade EAA+) on metabolomics, amino acid kinetics, metabolic rate, body composition in active adult women. The study consists of an acute randomized double-blind crossover phase comparing EAA+, whey protein isolate, and placebo before high-intensity interval training (HIIT), and a chronic randomized double-blind parallel-arm phase evaluating 3 weeks of EAA+ or placebo supplementation combined with twice-weekly HIIT.

Being studied: Essential Amino Acid+; Non-Calorie Placebo; High intensity Interval Training; No Exercise

Conditions: Healthy Women

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Participant is an adult between the ages of 25-45 years
  • Participant has a recorded BMI between 18.5-30 kg/m\^2
  • Participant is apparently healthy and free from disease, as determined by a health history questionnaire
  • Participant is a biological female
  • Participant is naturally menstruating or uses a form of hormonal contraceptive
  • Participant is recreationally active, based on the International Physical Activity Questionnaire- Short Form
  • Participant agrees to abstain from caffeine (12 hours), tobacco, alcohol, and exercise for 24 hours prior to testing days
  • Participant is willing and able to comply with the protocol

Exclusion Criteria

  • Participant has been diagnosed with chronic heart disease, arrhythmias, thyroid disease, renal, hepatic, autoimmune or neurological diseases, as determined by a health history questionnaire.
  • Participant has a musculoskeletal disorder or injury that would prohibit them from being able to safely complete the study protocol.
  • Participant is currently enrolled in a separate clinical trial or weight loss program involving diet, exercise, physical activity, or the potential ingestion of an active drug or dietary supplement
  • Participant is using, or has consistently used one of the following dietary supplements within 1 month prior to enrollment: whey protein, creatine, essential amino acids
  • Participant has a known allergy or sensitivity to the placebo or active ingredients
  • Participant is pregnant or planning to become pregnant
  • Participant does not speak English or is hearing impaired

Recruiting US locations

  • Applied Physiology Laboratory

    Chapel Hill, NC 27599

    Site contact: Research Coordinator · 919-962-1663 · aplresearch@unc.edu

Study contacts (from the official record)

  • Abbie Smith-Ryan, PhD · 919-962-2574 · abbiesmith@unc.edu
  • Research Coordinator · 919-962-1663 · aplresearch@unc.edu
All nutrition & metabolism studies in North Carolina →
Daily Upgrade Trial (NCT07792603) | Bored Studies