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Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment

Albert Einstein College of Medicine · with National Institute on Aging (NIA) · NCT07225400

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 65+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
30
US sites recruiting
2
Study start
September 15, 2026
Record last updated
September 11, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this one-arm clinical trial is to determine whether participants with mild cognitive impairment (MCI) can successfully navigate a virtual reality (VR) maze. The VR maze is designed as a training tool aimed at improving participants' spatial navigation abilities.

Main Aims

  • To determine whether at least 70% of older adults enrolled in the study can complete twenty-four 50-minute training sessions over a 4-month period.
  • To assess whether combining virtual reality with EEG recordings can be used to measure brain activation and changes in brain activation associated with spatial navigation learning.

Participants will

  • Walk in an open, unobstructed space while wearing VR goggles.
  • Explore up to fifty different virtual mazes in sequence and attempt to find their way through each one.

Being studied: Spatial Navigation training

Conditions: Mild Cognitive Impairment (MCI)

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age 65 and older with amnestic mild cognitive impairment (aMCI);
  • Can speak English;
  • Agrees to MoBI recording;
  • Normal or corrected-to-normal vision/audition;
  • Able to walk unassisted for 10 minutes;
  • Plan to be in the area for next year

Exclusion Criteria

  • Dementia (Memory Impairment/AD8 screen);
  • Medical conditions that affect participation such as vertigo and neck pain;
  • Hospitalization in the past six months or plans for surgery affecting participation in the next four months;
  • Mobility limitations solely due to musculoskeletal limitation or pain;
  • Terminal illness with life expectancy less than 12 months;
  • Presence of clinical disorders that overtly alter attention like delirium;
  • Active psychoses or psychiatric symptoms;
  • Living in nursing home;
  • Participation in intervention trial;
  • Standard contraindications to EEG including seizure medication, epilepsy, stroke, traumatic brain injury;
  • Pregnant women

Recruiting US locations

  • Columbia University Irving Medical Center

    Manhattan, NY 10032

    Site contact: Sunil Agrawal, PhD · 212-854-2993 · sa3077@columbia.edu

  • Albert Einstein College of Medicine

    The Bronx, NY 10461

    Site contact: Pierfilippo De Sanctis, PhD · 718-862-1828 · pierfilippo.sanctis@einsteinmed.edu

Study contacts (from the official record)

  • Pierfilippo De Sanctis, PhD · 718-862-1828 · pierfilippo.sanctis@einsteinmed.edu
  • Maya Hoff, BS · 7188397650 · maya.hoff@einsteinmed.edu
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