Skip to content
Bored Studies
RecruitingAccepts healthy volunteers

Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease

Cedars-Sinai Medical Center · NCT02301663

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–60 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
30
US sites recruiting
1
Study start
November 2014
Record last updated
September 1, 2023

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain, primarily impacts women. There are an estimated 2-3 million women in the US with MCD and about 100,000 new cases annually. Recent data from our research group suggests that coronary microvascular disease impairs the way the heart relaxes. This pilot study will attempt to exacerbate this phenotype in an effort to better understand the pathophysiology of the disease. The investigators will recruit 30 volunteers total (10 healthy calibration subjects, 10 women with microvascular disease, and 10 age-match women for the group with microvascular disease). Subjects will undergo a series of "stress" maneuvers in conjunction with advanced cardiac magnetic resonance imaging.

Being studied: Handgrip; Altitude simulation; Leg exercise

Conditions: Microvascular Coronary Dysfunction

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Fully understanding and willing to undergo study procedures
  • Male or Female greater than or equal to 18 years of age
  • Understanding and willing to sign consent form.

Exclusion Criteria

  • History of cardiovascular, pulmonary, or neurological disease
  • Hypertension (sitting blood pressure >140/90 mmHg, with measurements recorded on at least 2 occasions)
  • Diabetes
  • Unable to give informed consent;
  • Contra-indication to CMRI testing, including claustrophobia and metallic implants
  • Adherence or retention issues;
  • Women who are pregnant.
  • Allergy to animal dander.

Recruiting US locations

  • Cedars-Sinai Medical Center

    Los Angeles, CA 90048

    Site contact: Nicole Tovar · 310-248-6960 · nicole.tovar@cshs.org

Study contacts (from the official record)

  • Barbra Streisand Women's Heart Center · 310-423-9666
All heart & blood pressure studies in California →
Development of a Novel Stress Testing Protocol to Define the… (NCT02301663) | Bored Studies