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RecruitingAccepts healthy volunteersPhase 4

E-cigarette Cessation in Adults Who Co-use Cannabis

Medical University of South Carolina · with National Cancer Institute (NCI) · NCT06688539

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–40 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
105
US sites recruiting
3
Study start
February 19, 2025
Record last updated
June 12, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis. Varenicline is not FDA approved for e-cigarette cessation, but is FDA approved for cigarette cessation. Investigators are also interested in how cannabis/marijuana and tobacco interact during a tobacco quit attempt. All participants will receive e-cigarette cessation treatment for 12 weeks. To qualify, participants must be between the ages of 18-40 and use both e-cigarettes and cannabis. Participants do not need to be interested in quitting cannabis to qualify. This study is being conducted at three sites: the Medical University of South Carolina in Charleston, SC, Behavioral Health Services in Pickens, SC, and MUSC Lancaster in Lancaster, SC.

Being studied: Varenicline Pill; Contingency management; Counseling

Conditions: Nicotine Dependence; Tobacco Use Disorder

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Between the ages of 18 and 40 years old
  • Use e-cigarettes daily or near daily in the past month
  • Must submit a positive instant-read urine cotinine test at screening (≥ 200 ng/ml)
  • Be interested in quitting use of e-cigarettes
  • Must be willing to take varenicline for the standard 12-week course of treatment
  • Self-reported use of cannabis on at least 10 out of the past 30 days or must submit a positive qualitative urinary cannabinoid test at screening (> 50 ng/ml)

Exclusion Criteria

  • Any serious or unstable medical/psychiatric disorder (including severe substance use disorders, other than cannabis or tobacco use disorders) in the past three months that may interfere with study performance
  • Use of cigarettes on 10+ days in the past 30
  • Currently pregnant or breastfeeding
  • Current use of medications with smoking cessation efficacy
  • Use of any medications that would interfere with varenicline

Recruiting US locations

  • MUSC Charleston

    Charleston, SC 29425

    Site contact: Ela Williams · 843-497-4092 · williela@musc.edu

  • MUSC Lancaster

    Lancaster, SC 29720

    Site contact: Elizabeth Chapman · 864-898-2992 · chapmanb@musc.edu

  • Behavioral Health Services of Pickens County

    Pickens, SC 29671

    Site contact: Elizabeth Chapman, LPC · 864-898-2992 · chapmanb@musc.edu

Study contacts (from the official record)

  • Elizabeth Chapman, MA, LPC, LAC, AADC · 864.898.2992 · chapmanb@musc.edu
All smoking & vaping studies in South Carolina →
E-cigarette Cessation in Adults Who Co-use Cannabis (NCT06688539) | Bored Studies