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Early Detection of Advanced Adenomas and Colorectal Cancer

City of Hope Medical Center · NCT06342440

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
2000
US sites recruiting
2
Study start
March 15, 2020
Record last updated
July 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.

Being studied: DENEB

Conditions: Colorectal Cancer; Colorectal Neoplasms; Colorectal Polyp; Colorectal Adenocarcinoma; Colorectal Disorders; Colorectal Dysplasia; Colorectal Cancer Stage I; Colorectal Cancer Stage II; Colorectal Cancer Stage III; Colorectal Cancer Stage IV; Colorectal Neoplasms Malignant; Colorectal Serrated Adenocarcinoma; Colorectal Adenoma With Severe Dysplasia; Colorectal Adenoma With Mild Dysplasia; Colorectal Adenoma With Moderate Dysplasia; Colorectal Adenoma and Carcinoma 1; Colorectal Adenomatous Polyp; Colorectal Adenocarcinoma Metastatic in the Liver

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • All individuals included in the study need to have had a colonoscopy at the time of blood sampling.
  • Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment.
  • Received standard pathological and endoscopic diagnosis and assessment for cohort assignment.

Exclusion Criteria

  • Hereditary colorectal cancer syndromes (identified through genetic testing).
  • Inflammatory bowel diseases.
  • Lack of written informed consent.

Recruiting US locations

  • City of Hope Medical Center

    Monrovia, CA 91016

    Site contact: Ajay Goel, PhD · 626-218-3452 · AJGOEL@COH.ORG

  • University of California San Diego

    San Diego, CA 92093

    Site contact: C Richard Boland, MD, PhD

Study contacts (from the official record)

  • Ajay Goel, PhD · 6262183452 · AJGOEL@COH.ORG
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Early Detection of Advanced Adenomas and Colorectal Cancer (NCT06342440) | Bored Studies