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Early Onset Colorectal Cancer Detection

City of Hope Medical Center · NCT06342401

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–50 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
400
US sites recruiting
1
Study start
April 15, 2023
Record last updated
July 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagnosed CRC cases and it stands as the first cause of cancer-related death in young men and the second for young women.

This study aims to detect EOCRC with a non-invasive test, using a blood-based molecular assay based on microRNA (ribonucleic acid)

Being studied: ENCODE

Conditions: Colorectal Cancer; Colorectal Neoplasms; Colorectal Adenocarcinoma; Colorectal Cancer Stage I; Colorectal Cancer Stage IV; Colorectal Cancer Stage II; Colorectal Cancer Stage III; Colorectal Neoplasms Malignant

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Stage I, II, III, IV colorectal cancer (TNM classification, 8th edition) diagnosed before the age of 50 (EOCRC cases)
  • Received standard diagnostic and staging procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment
  • Colonoscopy-proven cancer-free status at the time of study inclusion (Non-disease controls)

Exclusion Criteria

  • Hereditary colorectal cancer syndromes (identified through genetic testing)
  • Inflammatory bowel diseases
  • Lack of written informed consent

Recruiting US locations

  • City of Hope Medical Center

    Duarte, CA 91010

    Site contact: Ajay Goel, PhD · 626-218-3452 · AJGOEL@COH.ORG

Study contacts (from the official record)

  • Ajay Goel, PhD · 626-218-3452 · AJGOEL@COH.ORG
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Early Onset Colorectal Cancer Detection (NCT06342401) | Bored Studies