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RecruitingAccepts healthy volunteersPhase 4

ED90 of Epidural Bupivacaine With Lidocaine for the Initiation of Labor Analgesia

Brigham and Women's Hospital · NCT05543694

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–50 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
120
US sites recruiting
1
Study start
October 1, 2022
Record last updated
July 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

To estimate the dose of bupivacaine required to achieve initial effective comfort in 90% of patients (ED90) via the epidural (DPE or EPL) technique in women undergoing labor after receiving a lidocaine "test dose"

Being studied: Bupivacaine Hydrochloride

Conditions: Labor Pain; Analgesia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Parturient with no major co-morbidities
  • Singleton, vertex gestation at term (37-42 weeks)
  • Less than or equal to 5 cm dilation
  • Desire to receive epidural labor analgesia
  • Numerical Rating Scale greater or equal to 5 (NRS 0-10, where 0 = no pain, and 10 = worst pain imaginable), at time of epidural labor analgesia request.

Exclusion Criteria

  • Current or historical evidence of clinically significant disease or condition, including diseases of pregnancy (i.e preeclampsia, gestational diabetes)
  • Any contraindication to the administration of an epidural technique
  • History of hypersensitivity or idiosyncratic reaction to an amide local anesthetic agent
  • Current or historical evidence of a disease which may result in the risk of a cesarean delivery (i.e. history of uterine rupture). NB: Exception-trial of labor after cesarean delivery (TOLAC) will be eligible.
  • Evidence of anticipated fetal anomalies

Recruiting US locations

  • Brigham and Women's Hospital

    Boston, MA 02115

    Site contact: Lawrence C Tsen, MD · 617-732-8216 · ltsen@zeus.bwh.harvard.edu

Study contacts (from the official record)

  • Lawrence C Tsen, MD · 617-732-8216 · ltsen@bwh.harvard.edu
All healthy volunteers studies in Massachusetts →
ED90 of Epidural Bupivacaine With Lidocaine for the Initiation of… (NCT05543694) | Bored Studies