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Effect of Cannabis on Cigarette Use Behavior

Johns Hopkins University · with National Institute on Drug Abuse (NIDA) · NCT06609083

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
100
US sites recruiting
1
Study start
January 22, 2025
Record last updated
January 16, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes. The study's goals are to test demand for cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke cigarettes and either smoke or vape THC in the laboratory.

Being studied: THC 30mg; THC 5mg; THC 0mg; Cigarette Full Nicotine; Cigarette Reduced Nicotine

Conditions: Cannabis Use; Tobacco Use; Cigarette Smoking

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Healthy non-treatment seeking adults aged 21 or older
  • Report daily use of combustible tobacco cigarettes
  • Biological confirmation of cigarette use: have an expired carbon monoxide (CO) level of more than 5 ppm and a positive urine cotinine test at screening
  • Report current use of cannabis (at least 1 occasion per week)
  • Have experience with the inhalation route of administration for cannabis
  • Biological confirmation of cannabis use: have a positive urinary THC drug test at screening.
  • For women of children bearing potential and men with female partners of child-bearing potential, must be willing to use an effective form of contraception during the study.

Exclusion Criteria

  • Report current intention to reduce or quit cannabis or tobacco use within the next 30 days
  • Meet Diagnostic and Statistical Manual (DSM-5) criteria for a substance use disorder other than alcohol, cannabis, or nicotine
  • Test positive for illicit drugs other than cannabis and tobacco
  • Positive breath alcohol test at study admission
  • Have a current physical or mental illness judged by the study team to negatively impact participant safety or scientific integrity
  • Have a lifetime history of suicidal behavior (i.e. past suicide attempt), or current suicidal behavior or ideation as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS)
  • Are currently pregnant, planning to become pregnant in the next three months or are currently breastfeeding
  • Have a history of clinically significant cardiac arrhythmias or vasospastic disease (e.g., Prinzmetal's angina)
  • Are currently enrolled in another clinical trial or have received any drug as part of a research study within 30 days of study participation.

Recruiting US locations

  • Johns Hopkins University Behavioral Pharmacology Research Unit

    Baltimore, MD 21224

    Site contact: Dustin Lee, PhD · 410-550-4035 · dlee214@jhmi.edu

Study contacts (from the official record)

  • Lauren Brogdon, MHS · 410-550-6953 · lmorri20@jhmi.edu
  • Dustin Lee, PhD · 410-550-4035 · dlee214@jhmi.edu
All smoking & vaping studies in Maryland →
Effect of Cannabis on Cigarette Use Behavior (NCT06609083) | Bored Studies