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RecruitingAccepts healthy volunteersEarly Phase 1

Evaluation of the Electronic Cigarette Withdrawal Syndrome

Johns Hopkins University · with National Institute on Drug Abuse (NIDA) · NCT06066996

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21–55 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
150
US sites recruiting
1
Study start
November 28, 2023
Record last updated
July 15, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this project is to rigorously evaluate the nature of e-cigarette withdrawal in exclusive e-cigarette users during a monitored abstinence period and the role of nicotine in the expression of this withdrawal syndrome.

Being studied: Transdermal Nicotine Patch; Placebo Nicotine Patch

Conditions: E-cigarette Use; Withdrawal

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion criteria

  • 21-55 years old
  • good general health as reviewed by study medical team
  • vital signs in normal range as reviewed by study medical team
  • negative urine test for illicit drug use (excluding THC) and negative breath alcohol test
  • daily use of a nicotine-containing e-cigarette for at least 6 months
  • no regular use of other tobacco products (e.g., smokeless products) for at least 6 months
  • urine cotinine >100ng/mL (i.e., recommended cutoff for confirming current nicotine use)
  • exhaled breath carbon monoxide (CO) \<6ppm
  • Penn State E-cigarette Dependence (PSED) score >=4, indicating mild dependence or greater
  • have an interest in reducing e-cigarette use

Exclusion criteria

  • psychoactive drug use (aside from cannabis, nicotine, alcohol, caffeine) in past month
  • current use of over-the-counter (OTC) or prescription medications that may impact safety
  • use cannabis >2 times per week
  • history of or current significant medical condition that would impact participation or safety according to the study investigators and medical staff
  • current psychiatric condition or substance use disorder (aside from tobacco use disorder) that would impact participation or safety according to the study investigators and medical staff
  • enrollment in another trial
  • positive pregnancy test
  • currently using a nicotine/tobacco cessation product
  • seizure disorder or traumatic brain injury (TBI)

Recruiting US locations

  • Behavioral Pharmacology Research Unit

    Baltimore, MD 21224

    Site contact: Justin Strickland, Ph.D. · 410-550-1975 · jstric14@jhmi.edu

Study contacts (from the official record)

  • Justin Strickland, Ph.D. · 4105501975 · jstric14@jhmi.edu
All smoking & vaping studies in Maryland →
Evaluation of the Electronic Cigarette Withdrawal Syndrome (NCT06066996) | Bored Studies