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Effect of Watermelon on Cardiometabolic Health

University of California, Los Angeles · with National Watermelon Promotion Board · NCT07006636

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Any age listed · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
22
US sites recruiting
1
Study start
April 1, 2026
Record last updated
July 31, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to determine whether consumption of 355 ml of watermelon juice will:

  • improve cardiovascular and overall metabolic health markers like blood pressure, heart rate, stiffness/flexibility of arteries (blood vessels), blood sugar, cholesterol), and gut hormones
  • contribute to the body's ability to protect itself from the potential cell damage caused by harmful chemical compounds (produced when skin is exposed to ultraviolet (UV) B light, for example). This will be evaluated by measuring how resistant skin is to the damage from UVB light exposure, as well as several markers of bodily stress blood and urine.

This will be determined immediately after consuming the juice (to evaluate the effects the juice has on health right away), as well as after 4 weeks of daily juice consumption (to evaluate the effects the juice has on health when consumed consistently over time).

Being studied: Watermelon Juice + liquid meal test at baseline; Sweetened placebo beverage +liquid meal test at baseline

Conditions: Cardiometabolic Health Indicators; Whole-body Antioxidant Capacity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Female
  • Generally healthy
  • Postmenopausal
  • BMI 25-40 kg/m2
  • Systolic blood pressure 120-139 mmHg and/or diastolic 80-89 mmHg
  • Fitzpatrick Skin type II-IV
  • Consume a typical Western diet (low in polyphenol/lycopene-rich foods and fiber)
  • Willing to maintain habitual dietary and exercise patterns for the study duration
  • Willing to maintain normal skin care products and pattern for the duration of the study
  • Willing to come to Baseline Visit B and Week 4 study visits without any makeup and skin products on
  • Subjects must read and sign the Institutional Review Board-approved written informed consent prior to the initiation of any study specific procedures or enrollment. A subject will be excluded for any condition that might compromise the ability to give truly informed consent.

Exclusion Criteria

  • Non-English speaker
  • Vegetarian/vegan
  • Known watermelon allergy
  • Skin-related prescription medication, supplements, or non-prescription cosmeceutical agents
  • Initiation of topical or oral prescription steroids and/or anti-inflammatory medications within 30 days prior to study enrollment
  • Excessive exposure to either natural or artificial sunlight. Exposure to sunlight will be evaluated using Fitzpatrick Skin Type test score. Individuals receiving scores higher than the upper cutoff of the proposed range for the specific skin type will be excluded
  • Screening laboratory values outside of the normal range that is considered clinically significant for study participation by the investigator
  • Documented chronic disease, including diabetes, renal or liver diseases, metabolic syndrome, active cancer, MI or stroke, history of gastric bypass or GI disease (e.g., Crohn's disease, IBD, diverticulosis, diverticulitis, etc.)
  • Taking medications or supplements known to affect metabolism or gut microbiota composition (antibiotics within the past 3 months, probiotics, fiber, etc.), unless willing to stop for the study duration
  • Taking exogenous hormones (e.g., hormone replacement therapy)
  • Recent weight fluctuations (>10% in the last 6 months)
  • Smoker or living with a smoker
  • Use of >20 g of alcohol per day
  • Unable or unwilling to comply with the study protocol (including unwillingness to avoid watermelon and other lycopene-rich foods for the whole duration of the study)
  • Unable to provide consent

Recruiting US locations

  • UCLA Center for Human Nutrition

    Los Angeles, CA 90095

    Site contact: Tatiana Diacova, PhD, MS, RD · 310-206-8292 · tdiacova@mednet.ucla.edu

Study contacts (from the official record)

  • Tatiana Diacova, PhD, MS, RDN · 3102068292 · tdiacova@mednet.ucla.edu
All healthy volunteers studies in California →
Effect of Watermelon on Cardiometabolic Health (NCT07006636) | Bored Studies