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Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

University of Colorado, Denver · with National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT06129110

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–70 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
70
US sites recruiting
1
Study start
January 31, 2024
Record last updated
May 15, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention. Researchers will then compare outcomes of individuals who lost weight to individuals who did not lose weight.

Being studied: Diet Weight Loss

Conditions: Obesity; Insulin Sensitivity; Muscle Weakness; Adiposity; Insulin Resistance

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Generally healthy men and women aged 18-70
  • BMI between 30-40
  • Less than 1 hour of exercise per week
  • Women:
  • may be pre or post menopausal

Exclusion Criteria

  • Type 1 or Type 2 diabetes
  • Thyroid disease
  • History of lung disease
  • Active use of nicotine
  • Severe plasma lipid disorders
  • Taking hormone replacement drugs, blood thinners, or thiazoladinediones
  • Women:
  • Currently going through menopause or peri-menopause
  • Pregnant or breastfeeding
  • History of Polycystic Ovary Syndrome

Recruiting US locations

  • University of Colorado Anschutz

    Aurora, CO 80045

    Site contact: Bryan Bergman, PhD

Study contacts (from the official record)

  • Bryan Bergman, PhD · 3037243919 · bryan.bergman@cuanschutz.edu
  • Sophia Bowen · 3037240487 · sophia.bowen@cuanschutz.edu
All weight loss studies in Colorado →
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling (NCT06129110) | Bored Studies