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Effects of P24 on Postprandial Aminoacidemia

Amplifye · NCT07479173

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 45–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
30
US sites recruiting
1
Study start
September 5, 2026
Record last updated
September 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to quantify the acute effects of an acid-active protease enzyme supplement (P24) on postprandial aminoacidemia following consumption of a standardized mixed-protein meal containing both plant- and animal-derived protein sources. Secondary objectives include evaluating the postprandial plasma peptidomic response, characterizing the postprandial hormonal responses (GLP-1, insulin, and GIP), and assessing the postprandial glucose response using standardized capillary blood glucose measurements. The study will also evaluate subjective responses including satiety and hunger and gastrointestinal symptoms.

Being studied: Protease enzyme supplement; Placebo

Conditions: Postprandial Amino Acid Concentrations in Healthy Adults

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Healthy adults aged 45-75 years
  • BMI 18.5-35 kg/m2
  • Able to provide informed consent and comply with study procedure
  • Willing to consume the standardized mixed-protein test meal

Exclusion Criteria

  • BMI outside of 18.5-35 kg/m2
  • Gastrointestinal disorders or malabsorption syndromes that could affect digestion/absorption (e.g., inflammatory bowel disease, celiac disease)
  • Diagnosed diabetes
  • Current use of medications or supplements that materially affect glucose metabolism or digestion (e.g., GLP-1 receptor agonists, chronic digestive enzyme supplementation)
  • Resting blood pressure ≥ 140/90 mmHg
  • Self-reported cancer within past 5 years
  • Known allergy or intolerance to meal components or capsule ingredients
  • Self-reported anemia or other conditions that increase risk from blood draws
  • Pregnancy or breastfeeding
  • Current smoking or nicotine use, heavy alcohol use (defined as > 5 drinks/day or > 15 drinks/week), or other factors that in the investigator's judgment make participation unsafe

Recruiting US locations

  • Ragle Human Nutrition Center

    Davis, CA 95616

    Site contact: Roberta H Holt, PhD · 530-400-5952 · rrholt@ucdavis.edu

Study contacts (from the official record)

  • Roberta Holt, PhD · 530-400-5952 · rrholt@ucdavis.edu
  • Holt · rrholt@ucdavis.edu
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Effects of P24 on Postprandial Aminoacidemia (NCT07479173) | Bored Studies