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Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff

Ohio State University Comprehensive Cancer Center · with National Institute on Drug Abuse (NIDA) · NCT06249984

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
80
US sites recruiting
1
Study start
December 20, 2024
Record last updated
August 17, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This clinical trial tests the effects of tobacco cut and nicotine form on the abuse liability in participants who use moist snuff (smokeless tobacco [SLT]). Two features of moist snuff that are key targets of manipulation from the tobacco industry and drivers of its addiction potential are length of tobacco cut (long versus fine) and nicotine form (low versus high levels of nicotine in the free-base form). Finer tobacco cuts and higher levels of free-base nicotine (FBN) result in faster, greater nicotine delivery. Researchers want to gain information on how certain characteristics of moist snuff affect how long people use it, how it delivers nicotine, or how much people like it. This clinical trial may provide justifications for local, state, or federal regulations aimed at reducing the appeal and addictiveness of moist snuff.

Being studied: Biospecimen Collection; Carbon Monoxide Measurement; Smokeless Tobacco Use; Survey Administration

Conditions: Tobacco-Related Carcinoma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adults aged 21 and older who reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification and use SLT daily for at least 3 months and using 1.5 cans/week will be considered for this project
  • Established moist snuff user (has used moist snuff daily for at least the past 3 months, uses at least 1.5 cans/week.
  • Age 21 years or older
  • Reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification
  • Willing to complete 5 study visits and provide informed consent study procedures, including abstaining from all tobacco, nicotine, and marijuana for 12 hours before clinic visits
  • Willing to abstain from nicotine and tobacco products 12-hours before study visit
  • Ability to read and speak English

Exclusion Criteria

  • Pregnant, planning to become pregnant, or breastfeeding (will be verified with a urine pregnancy test at the first session visit)
  • Unstable or significant psychiatric conditions (past and stable conditions will be allowed)
  • History of cardiac event or distress, including but not limited to uncontrolled high blood pressure, chest pain, and shortness of breath, within the past 3 months
  • Working with a cessation counselor, using cessation devices such as Chantix or Wellbutrin, or planning to quit within the next 3 months
  • Severe periodontal or oral lesions

Recruiting US locations

  • Center for Tobacco Research

    Columbus, OH 43214

    Site contact: Hayley Curran, MPH · 7402818555 · curran.144@osu.edu

Study contacts (from the official record)

  • The Ohio State Comprehensive Cancer Center · 800-293-5066 · OSUCCCClinicaltrials@osumc.edu
All smoking & vaping studies in Ohio →
Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of… (NCT06249984) | Bored Studies