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RecruitingAccepts healthy volunteersPhase 4

THRIVE Study: Understanding How Oral Nicotine Pouches Affect Public Health

Ohio State University Comprehensive Cancer Center · NCT07503925

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
15
US sites recruiting
1
Study start
June 26, 2026
Record last updated
August 17, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Although nicotine pouches have been gaining popularity over the last few years, little known about how nicotine pouch users actually use these products.

This study will be comprised of adults who use nicotine pouches. If eligible, participants will be asked to complete three study visits and participate in two switching periods where participants use study-provided nicotine pouches.

Being studied: Biospecimen Collection; Nicotine Oral Pouch; Nicotine Oral Pouch; Survey Administration; Text Message-Based Navigation Intervention

Conditions: Tobacco-Related Carcinoma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age 21 or older
  • Able to read and speak English
  • Willing to abstain from tobacco, nicotine, and marijuana for at least 12 hours prior to study visits
  • Exclusive use of ONPs (other product use \<10x/mo).
  • Exhaled CO reading \<10 ppm
  • Owns a smartphone and can receive SMS text messages with embedded survey links
  • Negative pregnancy test at V1 and V2 (if applicable)
  • Uses ≥1.5 cans of ONPs/week
  • Daily use of ONPs for the past 3 months
  • At least half of ONPs used are 6mg nicotine concentration.

Exclusion Criteria

  • Non-English speaker
  • Individuals currently pregnant, planning to become pregnant, or breastfeeding are excluded due to potential risks associated with nicotine exposure and study procedures (e.g., blood draws).
  • Individuals with unstable or significant psychiatric conditions are excluded to minimize risk and ensure reliable participation.
  • Individuals actively attempting to quit nicotine use are excluded to avoid ethical concerns and ensure that study participation does not interfere with cessation efforts
  • Non-nicotine users and regular tobacco users are excluded from the clinical trial component to ensure that participants have established use patterns appropriate for assessing ONP use behaviors.

Recruiting US locations

  • Ohio State University Comprehensive Cancer Center

    Columbus, OH 43210

    Site contact: Brittney L. Keller-Hamilton, PhD, MPH

Study contacts (from the official record)

  • The Ohio State University Comprehensive Cancer Center · 800-293-5066 · OSUCCCClinicaltrials@osumc.edu
All smoking & vaping studies in Ohio →
THRIVE Study: Understanding How Oral Nicotine Pouches Affect… (NCT07503925) | Bored Studies