Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults
University of Missouri-Columbia · NCT06689618
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 18+ · All sexes
- Healthy volunteers
- Accepted
- Study type
- Interventional · Not applicable
- Target enrollment
- 12
- US sites recruiting
- 1
- Study start
- August 18, 2025
- Record last updated
- February 17, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
During this pilot study, the investigators will examine the effects of whole-body electrical muscle stimulation exercise (WB-EMS Exercise) on motoneuronal activation in healthy adults, which typically decreases with age. The investigators will also test whether WB-EMS Exercise will improve measures of physical function. Participants will undergo clinical and electrophysiologic testing before and after the WB-EMS Exercise intervention. The WB-EMS Exercise intervention will be delivered two times per week for four weeks. The hypothesis is that whole-body electrical muscle stimulation combined with physical exercise (WB-EMS Exercise) could bypass the problem of insufficient motoneuronal activation to improve exercise effect in older adults.
Being studied: Exercise
Conditions: Aging; Sarcopenia; Sarcopenia in Elderly
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
Inclusion Criteria
- Age (65 years or older) for healthy older adults and between 18-39 for healthy younger adults
- Ambulatory without an assistive device
- More than anti-gravity strength in major muscle groups as assessed by manual muscle testing
- Medical clearance to participate in an exercise program
- Ability to conform to the requirements of the study (i.e. attendance at assessment and intervention visits, maintain current level of non-study physical activity for the duration of the study, no intention to relocate mid-study)
Exclusion Criteria
- Regular use of an assistive device for mobility (i.e. cane, walker, wheelchair)
- Presence of a pacemaker, metal implants, or other implanted medical devices that could impact participant safety during WB-EMS intervention
- Known pregnancy at the time of screening
- Presence of unstable acute or chronic disease (i.e. renal failure, rheumatologic disease cardia arrhythmia, neoplasm, uncontrolled hypertension)
- Presence of terminal disease (i.e. receiving hospice services)
- Current of previous use of any drugs known to influence muscle mass or performance within 6 months; these may include but are not limited to anabolic steroids, IGF01, growth hormone, replacement and androgen therapy, anti-androgen therapy.
- Known neuromuscular or neurologic condition affecting somatosensory or motor function/control (i.e. motor neuron disease, muscle disease, severe peripheral neuropathy, NMJ disease, Parkinson's disease, Multiple Sclerosis, h/o stroke, TBI, SCI, ataxia, apraxia, hemiplegia, etc.)
- Musculoskeletal condition or surgery in the past year that would confound results of exercise interventions (i.e. TKA, THA, RTC repair, spinal fusion)
- Other medical conditions, signs, or symptoms that would interfere with study conduct or interpretation of results as determined by a PI
Recruiting US locations
NextGen Precision Health Building, Clinical and Translational Science Unit
Columbia, MO 65211
Site contact: Manny Morales · 573-882-8571 · moralesman@missouri.edu
Study contacts (from the official record)
- Kristina Kelly, DPT, MS · 5738842596 · kristina.kelly@health.missouri.edu
- W. David Arnold, MD
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