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Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults

University of Missouri-Columbia · NCT06689618

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
12
US sites recruiting
1
Study start
August 18, 2025
Record last updated
February 17, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

During this pilot study, the investigators will examine the effects of whole-body electrical muscle stimulation exercise (WB-EMS Exercise) on motoneuronal activation in healthy adults, which typically decreases with age. The investigators will also test whether WB-EMS Exercise will improve measures of physical function. Participants will undergo clinical and electrophysiologic testing before and after the WB-EMS Exercise intervention. The WB-EMS Exercise intervention will be delivered two times per week for four weeks. The hypothesis is that whole-body electrical muscle stimulation combined with physical exercise (WB-EMS Exercise) could bypass the problem of insufficient motoneuronal activation to improve exercise effect in older adults.

Being studied: Exercise

Conditions: Aging; Sarcopenia; Sarcopenia in Elderly

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age (65 years or older) for healthy older adults and between 18-39 for healthy younger adults
  • Ambulatory without an assistive device
  • More than anti-gravity strength in major muscle groups as assessed by manual muscle testing
  • Medical clearance to participate in an exercise program
  • Ability to conform to the requirements of the study (i.e. attendance at assessment and intervention visits, maintain current level of non-study physical activity for the duration of the study, no intention to relocate mid-study)

Exclusion Criteria

  • Regular use of an assistive device for mobility (i.e. cane, walker, wheelchair)
  • Presence of a pacemaker, metal implants, or other implanted medical devices that could impact participant safety during WB-EMS intervention
  • Known pregnancy at the time of screening
  • Presence of unstable acute or chronic disease (i.e. renal failure, rheumatologic disease cardia arrhythmia, neoplasm, uncontrolled hypertension)
  • Presence of terminal disease (i.e. receiving hospice services)
  • Current of previous use of any drugs known to influence muscle mass or performance within 6 months; these may include but are not limited to anabolic steroids, IGF01, growth hormone, replacement and androgen therapy, anti-androgen therapy.
  • Known neuromuscular or neurologic condition affecting somatosensory or motor function/control (i.e. motor neuron disease, muscle disease, severe peripheral neuropathy, NMJ disease, Parkinson's disease, Multiple Sclerosis, h/o stroke, TBI, SCI, ataxia, apraxia, hemiplegia, etc.)
  • Musculoskeletal condition or surgery in the past year that would confound results of exercise interventions (i.e. TKA, THA, RTC repair, spinal fusion)
  • Other medical conditions, signs, or symptoms that would interfere with study conduct or interpretation of results as determined by a PI

Recruiting US locations

  • NextGen Precision Health Building, Clinical and Translational Science Unit

    Columbia, MO 65211

    Site contact: Manny Morales · 573-882-8571 · moralesman@missouri.edu

Study contacts (from the official record)

  • Kristina Kelly, DPT, MS · 5738842596 · kristina.kelly@health.missouri.edu
  • W. David Arnold, MD
Effects of Whole-body Electrical Muscle Stimulation Exercise on… (NCT06689618) | Bored Studies