Evaluating the Barrier Function, Regenerative Capacity, and Soft Tissue Outcomes of Acellular Dermal Matrix

Inclusion Criteria

• English speaking
• At least 18 years old
• Must be a patient of the UAB Dental School
• Able to read and understand informed consent document
• Patients presenting with a diagnosed need horizontal ridge augmentation with GBR without simultaneous implant placement, to allow for future dental implant placement.
• Presence of periodontally healthy, non-carious neighboring teeth and/or healthy restored dental implants on either side of the edentulous span planned for GBR, or unhealthy adjacent teeth to be extracted during the same visit.
• ≤4 mm ridge width in a Seibert Class I Edentulous span19
• No anticipated need for surgical and/or endodontic care at planned teeth adjacent to the proposed surgical site during the study period.

Exclusion Criteria

• Non-English speaking
• Less than 18 years old
• Smokers/nicotine users (defined as currently reporting use of any form of tobacco/nicotine products)
• Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing, including:

• Uncontrolled diabetes (HbA1c > 7%)
• Untreated periodontal disease
• History of head/neck radiation
• IV bisphosphonates
• Immunocompromised state
• Pregnancy
• Acute infection at site
• Documented or suspected allergy or sensitivity to any study product