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Evaluation of Brain MRI Changes in Cerebral Palsy Patients

Columbia University · NCT07433647

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Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–80 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
30
US sites recruiting
1
Study start
June 20, 2023
Record last updated
May 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Cerebral palsy (CP) is a neurodevelopmental syndrome characterized by sensorimotor impairment that arises during early childhood defined as a static insult to the developing brain. A key part of the definition for CP is a non-progressive brain injury; however, as individuals with CP age, a functional decline greater than neurotypical individuals is often present. The investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time.

This will be a single-center study that will compare retrospective clinical and imaging data with similar prospective data. The objective is to find out if people with Cerebral Palsy (CP) experience changes in the structures of their brain over time. A key part of the CP definition is that it is a non-progressive brain injury. However, as people with CP age, their function often deteriorates. This study seeks to determine whether changes in the brain structure may result in function changes, as they do in other types of brain injuries.

The investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States, as well as locally. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time.

Conditions: Cerebral Palsy; Spastic Diplegia; Spastic Quadriplegia; Spastic Hemiplegia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Have multiple MRI scans of brain and/or spinal cord spaced at least 24 months apart
  • Between 18-80 years of age with at least one MRI scan after the age of 18
  • No known central or peripheral neurological disease or injury other than cerebral palsy causing brain degeneration
  • Inclusion in CPRN registry
  • diagnosis of Cerebral Palsy
  • >18 years of age
  • Have received at least one past brain MRI scan as part of standard care (patients who have two or more brain MRI scans can be included in the retrospective arm only)

Exclusion Criteria

  • History of more than one seizure in lifetime
  • History of known degenerative genetic disorder
  • History of brain tumor, abscess, or multiple sclerosis
  • History of moderate or severe head trauma
  • History of metal implants in head

Recruiting US locations

  • Weinberg Family Cerebral Palsy Center, Columbia University

    New York, NY 10040

    Site contact: Jason Carmel, MD, PhD · 212-305-2700 · jbc28@cumc.columbia.edu

Study contacts (from the official record)

  • Jason Carmel, MD, PhD · 212-305-2700 · jbc28@cumc.columbia.edu
  • Shaker Dukkipati, MD, PhD · 212-305-2700 · sd3850@cumc.columbia.edu
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Evaluation of Brain MRI Changes in Cerebral Palsy Patients (NCT07433647) | Bored Studies