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Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)

University of Pennsylvania · NCT06545084

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
50
US sites recruiting
1
Study start
August 1, 2024
Record last updated
August 27, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of the study is to evaluate peri-radicular healing after root-end surgery using Leukocyte and Platelet Rich Fibrin. The study population includes patients diagnosed with persistent periapical pathology and scheduled for Endodontic Microsurgery at the University of Pennsylvania School of Dental Medicine, Department of Endodontics. Patients undergoing routine endodontic microsurgery and who meet the inclusion criteria will be given the opportunity to opt in to receive L-PRF in the osteotomy site to promote bone formation. Healing will be assessed radiographically and clinically at six, twelve, eighteen, and twenty-four months.

Being studied: Leukocyte and Platelet Rich Fibrin

Conditions: Apical Periodontitis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Provision of signed and dated informed consent form.
  • Stated willingness to comply with all study procedures and availability for the duration of the study, including the follow-up visits.
  • Male or Female age >18 years old.
  • In good general health (ASA 2 or less) with no contraindications for Endodontic Microsurgery.
  • Persistent endodontic periapical pathology Class A, B, or C according to the Kim and Kratchman classification (5)
  • Intact coronal restorations with no evidence of leakage or caries under the restoration.

Exclusion Criteria

  • Minors.
  • Suspected root fractures.
  • ASA classification 3 or greater.
  • Periapical pathology Class D, E, or F according to the Kim and Kratchman classification (5).
  • Patients with history of Oral or IV Bisphosphonate use.
  • Patients may be excluded if their treatment team do not believe Endodontic microsurgery and L-PRF graft is in the patient's best interests.

Recruiting US locations

  • Penn Dental Medicine

    Philadelphia, PA 19104

    Site contact: Bekir Karabucak, DMD · 215-898-6062 · bekirk@upenn.edu

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Evaluation of Periapical Healing Following Endodontic Microsurgery… (NCT06545084) | Bored Studies