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Examining Olive Oil Extract on Knee Comfort and Function

Applied Food Sciences Inc. · with Alethios, Inc. · NCT07514013

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 40–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
168
US sites recruiting
1
Study start
April 2026
Record last updated
April 15, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this study is to learn if an olive oil extract works to improve knee pain and discomfort in adults. The main questions it aims to answer are: 1) Does the olive oil extract improve the perceptions of knee pain and discomfort, and 2) Does the olive oil extract improve knee function in adults?

The main procedures in the study include

  • Screening and informed consent
  • Take one assigned study capsule (supplement or placebo) daily with food for 6 weeks
  • Complete digital questionnaires about your knee pain, stiffness, and function at scheduled times
  • Complete a Day 1 acute assessment and two simple functional movement tests at home as described below
  • If possible, connect a compatible wearable device to allow collection of sleep and physical activity data as detailed below.
  • Collect saliva samples at home using a provided kit at designated timepoints
  • Record any pain medications taken during the study or any side effects

Being studied: Olive Oil Extract; Placebo

Conditions: Healthy Adult Male; Healthy Adult Females; Joint Discomfort

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Participants must meet all of the following criteria to be eligible for participation:

  • Adults aged 40 to 75 years
  • Self-reported knee discomfort for at least 3 months
  • Willing and able to take one study capsule daily for the duration of the study
  • Willing and able to complete digital questionnaires, functional movement tasks, and other study activities using the Alethios platform
  • Willing and able to wear a compatible activity-tracking device throughout the study
  • Willing and able to collect saliva samples at home using a provided kit, if applicable
  • Able to read and understand English
  • Willing to provide informed consent electronically

Exclusion Criteria

Participants will be excluded if any of the following apply:

  • Diagnosis of inflammatory joint disease (e.g., rheumatoid arthritis) or other systemic inflammatory conditions affecting the knee
  • Any current or prior diagnosis from a licensed medical provider of knee disease
  • Knee surgery or significant knee injury within the past 6 months
  • Planned knee surgery during the study period
  • Known allergy or sensitivity to olive-derived products or any component of the study product
  • Current use of investigational drugs or participation in another research study during the study period
  • Any medical condition or circumstance that, in the opinion of the investigator, would make participation unsafe or interfere with study participation or data quality

Recruiting US locations

  • Alethios, Inc.

    San Francisco, CA 94104

    Site contact: Zeenia Framroze, MS · 650-208-8006 · zeenia@alethios.com

Study contacts (from the official record)

  • Christine Fields, PhD · 8475508978 · cfields@appliedfoods.com
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Examining Olive Oil Extract on Knee Comfort and Function (NCT07514013) | Bored Studies