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Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise

University of Southern California · NCT05934708

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–35 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
30
US sites recruiting
1
Study start
March 7, 2025
Record last updated
March 25, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. These sex hormones have also been purported to influence the perceived difficulty of exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and different recovery metrics.

Being studied: Eccentric leg extension

Conditions: Inflammatory Response

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18-35 years of age
  • BMI of 18.5-29.9 as a BMI below or above these cut points results in highly varied menstrual cycle lengths [15]
  • Not taking contraception or other types of medication that could influence reproductive status
  • Regular menstruation
  • Non-pregnant
  • Medically free from chronic diseases
  • Novel to downhill running
  • Weight greater than or equal to 110 lbs
  • Not taking exogenous hormones
  • Not suffering from known gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity

Exclusion Criteria

  • Amenorrhea or oligomenorrhea
  • Perimenopausal or menopausal
  • Recreational or professional trail or downhill runner
  • On a form of contraception
  • Cardiac disability
  • Pacemaker
  • Arterial disease
  • Uncontrolled hemorrhage
  • Blood clots
  • Pregnant or trying to become pregnant
  • Cancerous lesions
  • Sensory or mental impairment
  • Unstable fractures
  • Weight less than 110 lbs
  • Suffering from gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity
  • Taking exogenous hormones

Recruiting US locations

  • Clinical Exercise Research Center

    Los Angeles, CA 90033

    Site contact: Bailey McLagan, MS · 323-442-2180 · mclagan@usc.edu

Study contacts (from the official record)

  • Todd Schroeder, PhD · 3234422180 · eschroed@pt.usc.edu
All women’s health studies in California →
Examining the Role of Female Endogenous Sex Hormones in Eccentric… (NCT05934708) | Bored Studies