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Exercise and Carotid Artery Function in Metabolic Syndrome

University of Wisconsin, Madison · NCT07430839

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–40 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
48
US sites recruiting
1
Study start
December 1, 2025
Record last updated
March 25, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely improved with a single bout of exercise. This will be achieved by testing internal carotid artery function before and after a 30-minute bout of moderate intensity exercise. 48 young adults with and without metabolic syndrome will be enrolled and will be on study for approximately 5.5 hours over 4 study visits.

Being studied: exercise; Diagnostics; Inhaled CO2-mixed air

Conditions: Metabolic Syndrome

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria (MetSyn cohort):

  • Waist circumference greater than 102 cm (males) or 82 cm (females)
  • Triglycerides over 150 mg/dL
  • HDL cholesterol less than 40 mg/dL (males) or 50 mg/dL (females)
  • Blood pressure ≥130/85 mmHg
  • Fasting plasma glucose over 110 mg/dL

Inclusion Criteria (Healthy cohort):

  • meet age criteria

Exclusion Criteria

  • Current smoker, defined as more than 5 cigarettes over past 30 days
  • Current diagnosis or history of:
  • peripheral vascular disease
  • hepatic disease
  • renal disease
  • lung disease
  • gastrointestinal disorders/bleeding
  • hematologic disease
  • stroke
  • myocardial infarction
  • coronary heart disease
  • congestive heart failure
  • heart surgery
  • sleep apnea
  • autoimmune diseases
  • traumatic brain injury, concussion, stroke, or seizures
  • Asthma
  • Polycystic ovarian syndrome
  • Type II diabetes
  • Currently pregnant or breastfeeding
  • Current musculoskeletal injury Medication use known to influence cardiovascular function, other than oral contraceptives
  • Hormonal contraceptive use, such as intrauterine device or hormonal implant use
  • Participants with ICAs unsuitable for imaging, as assessed during the screening visit via doppler ultrasonography

Exclusion Criteria (healthy controls only):

  • BMI greater than 25 kg/m2
  • Blood pressure over 125/80 mmHg
  • Meeting any MetSyn criteria listed for MetSyn cohort

Recruiting US locations

Study contacts (from the official record)

  • Shawn Bolin, MS · 608-263-6308 · sbolin@wisc.edu
  • Logan Heenan, BS · 608-263-6308 · lheenan@wisc.edu
All nutrition & metabolism studies in Wisconsin →
Exercise and Carotid Artery Function in Metabolic Syndrome (NCT07430839) | Bored Studies