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RecruitingAccepts healthy volunteersEarly Phase 1

Exploring the Effects of an Intravaginal Lactic Acid Gel on the Vaginal Microbiome

Queen's Medical Center · with University of Hawaii Foundation · NCT05753813

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–54 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
22
US sites recruiting
1
Study start
December 15, 2023
Record last updated
February 20, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This project aims to investigate if the contraceptive method, Phexxi, causes changes to the composition of the vaginal microbiome. The investigators hypothesize that regular use of Phexxi will cause increased colonization of lactic acid-producing lactobacilli, which could have positive effects in the way of preventing recurrent episodes of BV and candida infections.

Being studied: Phexxi

Conditions: Bacterial Vaginosis; Vulvovaginal Candidiasis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age 18-54
  • Female
  • Pre-menopausal
  • Can speak and read in English
  • Displays capacity for informed consent
  • Has had 2 or more documented and/or self-reported episodes of symptomatic BV or candida infection in the last year, requiring, over-the-counter or prescription treatment

Exclusion Criteria

  • Pregnant or trying to become pregnant
  • Post-menopausal
  • Using NuvaRing device
  • A past medical history of kidney disease, recurrent UTI, and/or urinary tract abnormalities
  • Current UTI
  • Using Phexxi as a contraceptive during the collection period of the study

Recruiting US locations

  • Queens Medical Center, 1004 Clinic POB1

    Honolulu, HI 96813

    Site contact: Olivia H Manayan, MD, MPH · 8083487859

Study contacts (from the official record)

  • Olivia H Manayan, MD, MPH · 808-348-7859 · omanayan@hawaii.edu
All women’s health studies in Hawaii →
Exploring the Effects of an Intravaginal Lactic Acid Gel on the… (NCT05753813) | Bored Studies