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RecruitingAccepts healthy volunteers

Family Members at INcreased-risk for Developing Inflammatory Bowel Disease

Massachusetts General Hospital · NCT06655415

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 14+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
50
US sites recruiting
1
Study start
December 18, 2024
Record last updated
October 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

First-degree relatives of people with inflammatory bowel disease ("IBD," including Crohn's disease and ulcerative colitis) have an increased risk for developing IBD themselves. This study will follow unaffected first-degree relatives (who do not have IBD) over time to understand if their behaviors, diet, and biomarkers for IBD can help predict who gets IBD and if IBD can be prevented in these high-risk individuals. Participants will be asked once per year to complete a questionnaire and have their blood, stool, and urine collected. The anticipated length of the study (registry) is approximately 10 years or longer. Parts of this study, such as the questionnaires and stool and urine collection, may be done from home, while other parts, such as the blood draw, will need to be done from Massachusetts General Hospital.

Conditions: Inflammatory Bowel Disease (IBD); Ulcerative Colitis (UC); IBD-unclassified (IBD-U); Indeterminate Colitis; Crohn's Disease Colon; Crohn's Colitis; Crohn's Ileocolitis; Crohn's Gastritis; Crohn's Jejunitis; Crohn's Duodenitis; Crohn's Esophagitis; Ulcerative Proctitis; Ulcerative Proctosigmoiditis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Ability to give informed consent
  • Ability to complete all study visits and study-related procedures
  • Ability to understand and complete study questionnaires
  • Must have at least one first-degree relative with inflammatory bowel disease (Crohn's disease, ulcerative colitis, or IBD-unclassified)
  • Age ≥ 14

Exclusion Criteria

  • Individuals with existing diagnoses of inflammatory bowel disease (ulcerative colitis, Crohn's disease, or IBD-unclassified)
  • Evidence of clinical signs or symptoms of IBD, which will be identified on pre-screening interview with the study coordinator.

Recruiting US locations

  • Massachusetts General Hospital

    Boston, MA 02114

    Site contact: Emily W Lopes, MD, MPH · 617-726-5560 · mghfindibd@mgb.org

Study contacts (from the official record)

  • Emily W Lopes, MD, MPH · 617-726-5560 · mghfindibd@mgb.org
All healthy volunteers studies in Massachusetts →
Family Members at INcreased-risk for Developing Inflammatory Bowel… (NCT06655415) | Bored Studies