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Feasibility and Acceptability of Remote Saliva Collection

St. Jude Children's Research Hospital · with National Cancer Institute (NCI) · NCT07884474

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 8–18 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
100
US sites recruiting
1
Study start
October 2026
Record last updated
October 20, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to evaluate the practicality and acceptability of collecting biological samples and health information from childhood survivors of acute lymphoblastic leukemia (ALL) and their siblings. Participants will provide saliva, blood, hair, and fingernail samples, complete questionnaires, and participate in sleep monitoring. The information collected will help researchers understand how cancer treatment and neighborhood conditions may affect stress hormones, inflammation, and long-term health.

Primary Objective

  • To evaluate the feasibility of collecting multiple biological specimens, surveys, and sleep assessment among child and adolescent survivors of ALL and their siblings.

Being studied: Salivary Cortisol Collection; Blood Biomarker Collection; Hair Cortisol Collection; Nail Cortisol Collection; WatchPAT Sleep Assessment; Morning and Evening Diaries; MEMS Cap Adherence Monitoring; OnTimePoint Application; Survey and Questionnaire Assessment

Conditions: Survivors of Childhood Cancer; Acute Lymphoblastic Leukemia, Childhood

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

SURVIVORS

  • The survivor is a childhood survivor of Acute Lymphocytic Leukemia (ALL).
  • The survivor was treated on one of the following St. Jude Total Therapy Studies:
  • TOTAL Therapy study XVI for Newly Diagnosed Patients with ALL (TOTXVI) OR
  • Total Therapy for Children with Acute Lymphoblastic Leukemia and Lymphoma (TOT17)
  • The survivor is cancer-free.
  • The survivor is at least 5 years out from the ALL diagnosis.
  • The survivor is at least 2 years out from completion of treatment.
  • The survivor did not receive cranial therapy as part of ALL therapy.
  • The survivor is aged ≥8 to 18 years old at the time of enrollment.
  • The survivor has completed their After Completion of Therapy (ACT) clinic consultation.
  • The survivor is able to speak and read English.
  • The survivor has internet access.

SIBLINGS

  • The sibling has a brother or sister who is an ALL survivor participating in this study.
  • The sibling is aged ≥8 to18 years old at the time of enrollment.
  • The sibling is able to speak and read English.
  • The sibling has internet access.

CAREGIVERS

  • The caregiver provides primary care or support to an ALL survivor that is in this study.
  • The caregiver resides in the home full-time with enrolled survivor and sibling.
  • The caregiver is able to speak and read English.
  • The caregiver has internet access.
  • The caregiver is willing and able to assist with at home biospecimen collection.

Exclusion Criteria

SURVIVORS and SIBLINGS

  • Survivor and/or sibling has a diagnosis of Down's Syndrome.
  • Survivor and/or sibling has a diagnosis of autism spectrum disorder.
  • Survivor and/or sibling has a diagnosis of another pervasive developmental disorder not listed above.
  • Survivor and/or sibling has a history of prolonged treatment with steroid medications or systemic glucocorticoids for reasons other than ALL.
  • Survivor and/or sibling resides outside of the United States.
  • Inability or unwillingness of survivor and/or sibling and/or legal guardian/representative to give written informed consent.

CAREGIVERS Note: There are no exclusion criteria for caregivers.

Recruiting US locations

  • St. Jude Children's Research Hospital

    Memphis, TN 38105

    Site contact: Bria Gresham, PhD · 866-278-5833 · referralinfo@stjude.org

Study contacts (from the official record)

  • Bria Gresham, PhD · 866-278-5833 · referralinfo@stjude.org
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Feasibility and Acceptability of Remote Saliva Collection (NCT07884474) | Bored Studies