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fMRI in CardiaC arrEst With Uncertain Prognosis

Brigham and Women's Hospital · with American Heart Association · NCT06423768

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
50
US sites recruiting
1
Study start
May 16, 2024
Record last updated
June 22, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this observational study is to determine whether specific advanced MRI measures are associated with functional outcomes in patients who are comatose after cardiac arrest. The main question[s] it aims to answer are:

Aim 1: Determine if stimulus-based functional MRI (fMRI)-measured activations are independently associated with favorable neurological outcomes after cardiac arrest

Aim 2: Determine if resting state functional MRI (rs-fMRI)-measured functional network connectivity is independently associated with favorable neurological outcomes after cardiac arrest.

Aim 3: Determine if diffusion tensor imaging (DTI)-measured white matter integrity is associated with favorable neurological outcomes after cardiac arrest.

Participants will undergo advanced MRI sequences at time of clinical MRI, and will be followed for 6 months post-arrest.

Conditions: Cardiac Arrest

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • survive of an in or out of hospital cardiac arrest

Exclusion Criteria

  • Drug overdose
  • Opinion of medical team patient unlikely to survive more than 24 hours (severe concurrent medical illness, dilated and unreactive pupils, etc..)
  • Following verbal commands (MD or RN note) once TTM is complete and normothermia is achieved (Day 2 or 3; Day of admission is Hospital Day 0). If no TTM is administered, this can be assessed on Hospital Day 2.
  • Following verbal commands (study team assessment) at time of MRI
  • Family planning to WLST at time of enrollment
  • Non English speaker (okay if English not primary language, as long as they can understand it)
  • Permanent Contraindication to MRI (some kind of implanted metal)
  • Pregnant

Recruiting US locations

  • Brigham and Women's Hospital

    Brookline, MA 02114

    Site contact: Sam Snider · 9196142137 · ssnider@partners.org

Study contacts (from the official record)

  • Samuel B Snider, MD · 857-307-2391 · ssnider@bwh.harvard.edu
All healthy volunteers studies in Massachusetts →
fMRI in CardiaC arrEst With Uncertain Prognosis (NCT06423768) | Bored Studies