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RecruitingAccepts healthy volunteersPhase 2/Phase 3

Focusing on the Menopausal Transition to Improve Mid-Life Women's Health

University of Colorado, Denver · NCT06975111

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 45–55 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Phase 2, Phase 3
Target enrollment
200
US sites recruiting
3
Study start
March 1, 2026
Record last updated
July 21, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

What if midlife women, who are inherently at an increased risk for future cardiometabolic disease due to transitioning into menopause, had access to a suite of evidence-based health interventions? Could these interventions reduce menopause-related inflammation, restore a healthier cardiometabolic profile, reverse epigenetic aging, and reduce bothersome menopausal symptoms? The ultimate goal of this work is to attenuate future disease and enhance women's quality of life, extend healthspan and increase productivity.

Being studied: Metformin; semaglutide; Anti-hypertensives; Lipid Lowering Medication; Life style intervention; Fezolinetant; Hormonal therapy

Conditions: Menopause; Menopause Hot Flashes; Menopause Related Conditions; Cardiovascular

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • aged 45-55
  • In the late menopausal transition, defined as 60 days of amenorrhea but less than 365 days of amenorrhea18
  • No current use of hormone therapy or hormonal contraception
  • Presence of a uterus and at least one ovary in order to track menstrual patterns
  • Have a smartphone and broadband access adequate to accept telehealth appointments

Exclusion Criteria

  • Lack of broadband access (activity and survey data will be collected electronically whenever possible and some visits will be via telehealth)
  • Lack of regular menstrual periods in mid-reproductive life (ages 25-38) when not on hormones or not pregnant.
  • Pregnancy or actively trying to get pregnant
  • Inability to adhere to study protocol schedule
  • Untreated alcoholism
  • Un- Diagnosed abnormal uterine bleeding
  • Personal or family history of medullary thyroid cancer or multiple endocrine neoplasia (MEN 2) for participants with a BMI> 30 kg/m2.

Recruiting US locations

  • University of Colorado-School of Medicine

    Aurora, CO 80045

  • University of North Carolina, School of Medicine

    Chapel Hill, NC 27599

    Site contact: Chelsea A Grinnan, RN · 919-908-0010 · REI_research@med.unc.edu

  • Virginia Commonwealth University

    Richmond, VA 23298

    Site contact: Keila Najera, MPH · 804-221-5159 · Keila.najera@vcuhealth.org

Study contacts (from the official record)

  • Carrie Hsu, BA · 303-724-5276 · carrie.hsu@cuanschutz.edu
  • Nalia Naushad · naila.naushad@cuanschutz.edu
All women’s health studies in Colorado →
Focusing on the Menopausal Transition to Improve Mid-Life Women's… (NCT06975111) | Bored Studies