RecruitingAccepts healthy volunteers

Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

Case Western Reserve University · with University Hospitals Cleveland Medical Center, Washington University School of Medicine · NCT00288119

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Status re-checked against ClinicalTrials.gov within the last 12 hours.

The overall objectives of this BETRNet Research Center (RC) are:

to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (ECA)
to increase the biological understanding of key observations made by our clinical researchers;
to translate knowledge derived from genetic, epigenetic, and transcriptome research to solving clinical dilemmas in detection, prognosis, prevention, and therapy of BE in order to prevent EAC and improve the outcomes of EAC;
to foster a transdisciplinary and translation research culture and to effectively expand and enhance scientific research focused on BE and EAC;
to evaluate research and transdisciplinary programs and to continuously improve research, productivity and enhance translational implementation. These objectives build and synergize on existing multi-institutional collaborative networks and the considerable clinical, basic science, and translational expertise available at our institutions, focusing on improving the outcomes of patients with BE and EAC. The overarching organization framework for this RC proposal is 1) to focus laboratory research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of BE and EAC; and 2) to then translate laboratorydiscoveries into clinical applications for effective detection, molecular risk stratification, and prevention of progression from BE to EAC.

Being studied: Balloon Capsule Device; Endoscopy

Conditions: Barrett's Esophagus; Esophageal Neoplasm

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Eligible cases will be defined as those patients and their family members who meet the following criteria:

Barrett's esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus.
Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent.
Ability to give informed consent, if patient is age 18 or older.

Johns Hopkins Hospital
Baltimore, MD 21205
Site contact: Marcia Canto, M.D. · (410) 614-5388
Mayo Clinic
Rochester, MN 55905
Site contact: Ganapathy A Prasad, M.D. · (507) 255-6930 · Prasad.Ganapathy@Mayo.edu
Washington University School of Medicine
St Louis, MO 63110
Site contact: Jean Wang, MD · 314-362-5952 · jwang@DOM.wustl.edu
Columbia University Medical Center
New York, NY 10032
Site contact: Julian Abrams, MD · 212-342-0476 · ja660@mail.cumc.columbia.edu
University of North Carolina at Chapel Hill
Chapel Hill, NC 27599
Site contact: Nicholas J Shaheen, M.D. · 919-966-2513 · nshaheen@med.unc.edu
University Hospitals of Cleveland
Cleveland, OH 44106-8066
Site contact: Amitabh Chak, MD · 216-844-5386 · axc22@po.cwru.edu
Cleveland Clinic
Cleveland, OH 44195
Site contact: Prashanthi Thota, MD · 216-444-0780 · THOTAP@ccf.org
University of Pennsylvania
Philadelphia, PA 19104
Site contact: Gary W Falk, MD, MS · 215-615-6588 · Gary.Falk@uphs.upenn.edu
VA Puget Sound Health Care System
Seattle, WA 98108
Site contact: Andrew Kaz, MD
Fred Hutchinson Cancer Research Center, UWMC
Seattle, WA 98109
Site contact: William Grady, MD · 206-667-1107 · wgrady@fhcrc.org