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Growth Hormone Resistance of Beta-cells A

University of Missouri-Columbia · NCT06571487

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–45 · Women only
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
30
US sites recruiting
1
Study start
October 22, 2025
Record last updated
May 11, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes.

Conditions: Gestational Diabetes; Obesity; Healthy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Singleton, full term pregnancy within the past 5 years
  • Body mass index ≥18.5 kg/m2 and \<45.0 kg/m2

Group specific inclusion criteria

  • Gestational Diabetes Group: History of gestational diabetes in the most recent pregnancy
  • Control Group: no history of gestational diabetes

Exclusion Criteria

  • Pregnant, planning to become pregnant during the study, or breastfeeding
  • Current diagnosis or history of type 1 or type 2 diabetes
  • Use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)
  • History of bariatric surgery
  • Known, uncontrolled hypothyroidism
  • History of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment
  • Current cancer or cancer that has been in remission less than 5 years
  • First degree relative with diabetes diagnosis
  • Evidence of significant anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease)
  • Alcohol use disorder, use of controlled substances, or smoking >2 cigarettes per day
  • Greater than 3% weight loss within three months of screening or engaged in regular (≥3 days per week), continuous moderate- or high-intensity exercise of ≥30 min duration
  • Mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent

Recruiting US locations

  • University of Missouri School of Medicine

    Columbia, MO 65212

    Site contact: Bettina Mittendorfer · 573-882-9377 · b.mittendorfer@missouri.edu

Study contacts (from the official record)

  • Amanda Heider · 573-884-6852 · ahmc4@health.missouri.edu
  • Vasavi Shabrish, PhD · v.shabrish@missouri.edu
All weight loss studies in Missouri →
Growth Hormone Resistance of Beta-cells A (NCT06571487) | Bored Studies