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HEPA, PM2.5, and Cardiometabolic Health

University of Southern California · with Duke University · NCT05718245

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 65–84 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
52
US sites recruiting
1
Study start
March 15, 2023
Record last updated
August 1, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.

Being studied: HEPA filter; Sham filter

Conditions: Air Pollution; Cardiometabolic Health

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age between 65 and 84 years old;
  • Nonsmoker for at least 1 year;
  • History of BMI ≥ 25 kg/m2 in the past based on EMR information;
  • Either an English or Spanish speaker;
  • Live in the Los Angeles County.

Exclusion Criteria

  • History of diabetes (both type 1 and type 2) or degenerative disease of the nervous system (Alzheimer's disease or dementia);
  • Currently have active cancer treatment;
  • The residential house has already had HEPA filters;
  • Participants will move out of the current house in the next 2 years;
  • Participants will spend more than one month living outside the primary home;
  • Have any health conditions that prohibit collecting health and covariate data and biospecimen;
  • The residential houses are not feasible for setting up air purifiers and air pollutants monitors;
  • Have high blood glucose from finger stick test (> 200 mg/dL).

Recruiting US locations

  • Keck School of Medicine, University of Southern California

    Los Angeles, CA 90033

    Site contact: Zhanghua Chen, PhD · 323-442-2109 · zhanghuc@usc.edu

Study contacts (from the official record)

  • Zhanghua Chen, PhD · 323-442-2109 · zhanghuc@usc.edu
  • Junfeng Zhang, PhD · 919-681-7782 · junfeng.zhang@duke.edu
All healthy volunteers studies in California →
HEPA, PM2.5, and Cardiometabolic Health (NCT05718245) | Bored Studies