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High Resolution Retinal Imaging

University of Pennsylvania · with National Eye Institute (NEI) · NCT01866371

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 7+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
600
US sites recruiting
1
Study start
May 2013
Record last updated
May 5, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Studying the morphology and function of the normal and diseased retina in vivo is needed for advancing the detection, diagnosis, and treatment of retinal disease. This protocol uses an adaptive optics scanning laser ophthalmoscope (AOSLO) to image the normal and diseased retina with individual cellular resolution non-invasively. The primary objective of this study is to obtain and analyze high-resolution images of the retina, in particular by imaging the cone photoreceptor mosaic, the retinal vasculature and other retinal layers. The study design will involve case-control studies, where cases are followed over time. Subjects age 7 and older may be invited to participate. The main research procedure involves retinal imaging with the AOSLO. The primary endpoint is the observation of differences in retinal images between subjects with and without retinal diseases. These changes will be quantified by examining the cell density, size, spacing and regularity of the cone photoreceptor mosaic, as well as examining the differences between other retinal layers.

Being studied: Retinal imaging

Conditions: Stargardts; Retinitis Pigmentosa; Age-related Macular Degeneration; Choroideremia; Geographic Atrophy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Males or females age 7 years or older.
  • Parental/guardian permission (informed consent) and if appropriate, child assent. Child subjects age 7-17 must give assent.
  • Reasonable compliance with an imaging protocol as determined by the study personnel.

Exclusion Criteria

  • Individuals that are at risk to acute glaucoma.
  • Individuals that are photophobic and experience adverse psychological reactions to flashes of light.
  • Ocular opacities, high refractive error, and high frequency of nystagmus as determined by the study team.

Recruiting US locations

  • University of Pennsylvania

    Philadelphia, PA 19104

    Site contact: Jessica IW Morgan, PhD · 215-614-4196 · jwmorgan@pennmedicine.upenn.edu

Study contacts (from the official record)

  • Jessica IW Morgan, PhD · 215-614-4196 · jwmorgan@pennmedicine.upenn.edu
All healthy volunteers studies in Pennsylvania →
High Resolution Retinal Imaging (NCT01866371) | Bored Studies