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Hippocampal Oscillations During Exploration

NYU Langone Health · with National Institute on Deafness and Other Communication Disorders (NIDCD) · NCT07224191

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–70 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
56
US sites recruiting
1
Study start
February 25, 2026
Record last updated
July 8, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices.

Being studied: Visual Exploration; Ambulatory Exploration

Conditions: Epilepsy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

All subjects

  • Adults (18-70 years)
  • Able to provide informed consent

Aim 1: Surgical epilepsy patients' inclusion criteria

  • Implanted hippocampal depth electrodes for Stage 1 epilepsy surgery
  • MMSE>=24

Aim 2: RNS patients Inclusion criteria

  • Implanted RNS device with at least one hippocampal depth electrode
  • At least 5 months post-implantation to avoid the post-implant effect
  • Have a relatively low number of seizures, defined as \<1 generalized tonic-clonic or other seizure with potential to fall or cause injury per month
  • Able to walk and wear research equipment without assistance
  • MMSE>=24

Aim 2: Healthy Control Inclusion criteria • Able to walk and wear research equipment without assistance

Exclusion Criteria

RNS patients, Aim 2:

  • Any generalized tonic-clonic seizure within the last week

All subjects

  • Legally blind
  • Smoking tobacco, marijuana, recreational drugs or alcohol use within 1 week of cognitive testing
  • Unable to give informed consent
  • Pregnancy

Recruiting US locations

Study contacts (from the official record)

  • Anli Liu, MD, MA · (929) 455-2323 · Anli.Liu@nyulangone.org
  • Ayelet Rosenberg · (646) 558-0893 · Ayelet.rosenberg@nyulangone.org
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Hippocampal Oscillations During Exploration (NCT07224191) | Bored Studies