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RecruitingAccepts healthy volunteersEarly Phase 1

Imaging CRF X NOP Interactions in CUD

Rajesh Narendran · with National Institute on Drug Abuse (NIDA) · NCT05008146

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–55 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
80
US sites recruiting
1
Study start
December 31, 2020
Record last updated
July 6, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study uses [11C]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC). It will also examine whether alterations in CRF x NOP interactions predict relapse in subjects with CUD.

Being studied: Baseline [C-11]NOP-1A PET Scan; Hydrocortisone; Post-hydrocortisone [C-11]NOP-1A PET Scan

Conditions: Cocaine Use Disorder

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Cocaine use disorders (CUD)

  • Males or females between 18 and 55 years old
  • Fulfil DSM-5 criteria for cocaine use disorder
  • No other current DSM-5 psychiatric or addictive disorders (such as major depressive disorder, bipolar disorders, psychotic disorders, etc.,)
  • No current abuse (six months) of opiates, sedative-hypnotics, amphetamines, MDMA, etc., as well as moderate to severe alcohol or cannabis use (twice a week). Nicotine use will be quantified and controlled between groups using the Fagerstrom Test for Nicotine Dependence (Heatherton et al., 1991);
  • Not currently on prescription medical or psychotropic medications
  • No current or past severe medical, endocrine or neurological illnesses including glaucoma, seizure disorders, hypertension, hypercholesterolemia as assessed by a complete medical history and physical
  • Not currently pregnant or breastfeeding
  • No history of significant radioactivity exposure in past year from another research study or occupation that exceeds RDRC guidelines
  • No metallic objects in the body that are contraindicated for MRI

Healthy Controls (HC)

  • Males or females between 18 and 55 years old
  • No present or past DSM-5 disorders (other than nicotine dependence)
  • Criteria 5 to 9 as listed previously.

Recruiting US locations

  • University of Pittsburgh

    Pittsburgh, PA 15213

    Site contact: Rajesh Narendran · 4126475176 · narendranr@upmc.edu

Study contacts (from the official record)

  • Rajesh Narendran, MD · 4126475176 · narendranr@upmc.edu
All healthy volunteers studies in Pennsylvania →
Imaging CRF X NOP Interactions in CUD (NCT05008146) | Bored Studies