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Imaging Histone Deacetylase in the Heart

Massachusetts General Hospital · NCT03549559

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–85 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
96
US sites recruiting
1
Study start
September 7, 2018
Record last updated
December 22, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The overall goal of this PET-MR imaging trial is to evaluate 11C-Martinostat, a histone deacetylase targeted radioligand, in patients with aortic stenosis, individuals with diabetes, and healthy volunteers.

Being studied: 11C-Martinostat; PET-MRI

Conditions: Heart Failure With Normal Ejection Fraction; Left Ventricular Hypertrophy; Aortic Valve Stenosis; Diabetes

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Group 1: Healthy Volunteers (n = 30)

  • Healthy adults with no known history of medical disease
  • Age 18-85 years
  • No history cardiovascular disease
  • Ability to provide informed consent

Group 2: Patients with Diabetes (n = 16)

  • Age 18-85 years
  • Diagnosis of diabetes
  • Echocardiogram within last 12 months showing no evidence of left ventricular hypertrophy or hemodynamic findings consistent with heart failure with preserved ejection fraction
  • Ability to provide informed consent

Group 3: Patients with Aortic Stenosis (n = 50)

  • Age 18-85 years
  • Echocardiogram or cardiac MRI scan within last 12 months documenting left ventricular hypertrophy and degenerative calcific aortic stenosis
  • Ability to provide informed consent

Exclusion Criteria

  • Known contraindication to MRI

Recruiting US locations

  • Massachusetts General Hospital

    Boston, MA 02114

    Site contact: David Sosnovik, MD

Study contacts (from the official record)

  • David E Sosnovik, MD · 617-724-3407 · dsosnovik@mgh.harvard.edu
  • Anne L Philip, MPH · 617-726-0431 · alphilip@mgh.harvard.edu
All diabetes studies in Massachusetts →
Imaging Histone Deacetylase in the Heart (NCT03549559) | Bored Studies