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Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors

St. Jude Children's Research Hospital · NCT06819475

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
60
US sites recruiting
1
Study start
June 2, 2025
Record last updated
September 17, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The participants are being asked to take part in this trial, because the participant is a survivor of childhood cancer or agreed to be part of a volunteer group to understand the relation between cancer and cancer treatment and muscle weakness in survivors of Acute Lymphoblastic Leukemia (ALL). ALL is cancer of the blood and bone marrow.

Primary Objective

  • To compare muscle mtOXPHOS activity and satellite cell content among ALL survivors and controls.

Secondary Objective

  • To evaluate the association between muscle mtOXPHOS, muscle satellite cell content and physical performance in ALL survivors.
  • To evaluate the association of muscle morphology and epigenetics with muscle mtOXPHOS in ALL survivors.

Being studied: Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Physical function assessment; Peripheral blood sample; Skeletal muscle biopsy; Muscle Ultrasound

Conditions: Childhood Cancer; Muscle Weakness

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Survivor- or Control-Participant is age 18 years old or older at time of consent and enrolled in SJLIFE.
  • Survivor- Participant is childhood ALL survivor
  • Survivor- or Control Participant has low muscle mass as defined by relative lean mass z-score of less than or equal to -0.5 SD (lean mass divided by height in meters squared).
  • Survivor - Participant is able and willing to give informed consent

Exclusion Criteria

  • Survivor-Participant has history of cranial radiation.
  • Survivor- or Control-Participant has implanted medical devices or metal that would interfere with MRI or MRS
  • Female Survivor- or Control-Participant is pregnant.
  • Survivor- or Control-Participant is taking anticoagulants (e.g. aspirin, apixaban, coumadin, edoxaban, rivaroxaban)
  • Survivor- or Control-Participant weighs more than 300 pounds.
  • Survivor- or Control-Participant is allergic to local anesthetic (i.e., lidocaine, bupivacaine).
  • Survivor- or Control-Participant cannot lie flat on his/her back for 90 minutes or longer
  • Survivor- or Control-Participant has a current history of peripheral motor neuropathy.

Recruiting US locations

  • St. Jude Children's Research Hospital

    Memphis, TN 38105

    Site contact: Puneet Bagga, PhD · 888-226-4343 · referralinfo@stjude.org

Study contacts (from the official record)

  • Puneet Bagga, PhD · 888-226-4343 · referralinfo@stjude.org
  • Puneet Bagga, PhD · referralinfo@stjude.org
All healthy volunteers studies in Tennessee →
Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute… (NCT06819475) | Bored Studies