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Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke

University of Pittsburgh · with Northwestern University, National Institute on Deafness and Other Communication Disorders (NIDCD) · NCT06458153

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Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
100
US sites recruiting
1
Study start
May 27, 2025
Record last updated
June 18, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are:

  • What regions of the brain's sensory systems show changes in their activity related to speech?
  • To what extent do these regions help listeners detect and correct speech errors?
  • What is the role of the cerebellum (a part of the brain in the back of the head) in these activities?

Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).

Being studied: Neural responses to speech functional localizer; Neural responses to silent articulation; Neural responses to self vs. externally generated speech; Event-related potentials for speech; Neural responses to induced speech errors; Neural responses to sensory-motor adaptation; Speech production behaviors; Auditory acuity testing; Neural responses to learning a non-speech auditory motor behavior

Conditions: Stroke; Cerebellum

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Cohort 1 (neurotypical adults):

  • Age 18-49
  • Right-handed
  • Native English speaker

Cohort 2 (people with cerebellar lesions):

  • Age 18 or older
  • Right-handed
  • Native English speaker
  • History of cerebellar stroke

Cohort 3 (controls matched to Cohort 2)

  • Age 18 or older
  • Right-handed
  • Native English speaker

Exclusion Criteria

Cohort 1 (neurotypical adults):

  • Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
  • History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
  • Hearing loss, defined by pure tone thresholds >25 decibels (dB) hearing level (HL) at octave frequencies between 250-8000 Hz
  • Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
  • Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
  • Presence of a severe and unmanaged, clinically diagnosed attention disorder
  • Clinically diagnosed with or treated for a speech, language, or hearing disorder
  • Head circumference greater than 60cm or weight greater than 300 pounds
  • History of severe claustrophobia
  • Currently pregnant

Cohort 2 (people with cerebellar lesions):

  • Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
  • History of neurological / neurodegenerative disease or severe brain injury other than stroke
  • Hearing loss, defined by pure tone thresholds >50 dB HL at octave frequencies between 250-4000 Hz
  • Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
  • Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
  • Presence of a severe and unmanaged, clinically diagnosed attention disorder
  • Head circumference greater than 60cm or weight greater than 300 pounds
  • History of severe claustrophobia
  • Currently pregnant

Cohort 3 (controls matched to Cohort 2):

  • Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
  • History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
  • Hearing loss, defined by pure tone thresholds >50 dB HL at octave frequencies between 250-4000 Hz
  • Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
  • Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
  • Presence of a severe and unmanaged, clinically diagnosed attention disorder
  • Clinically diagnosed with or treated for a speech, language, or hearing disorder
  • Head circumference greater than 60cm or weight greater than 300 pounds
  • History of severe claustrophobia
  • Currently pregnant

Recruiting US locations

  • University of Pittsburgh

    Pittsburgh, PA 15260

    Site contact: Jason Bohland, Ph.D. · 412-383-3416 · j.bohland@pitt.edu

Study contacts (from the official record)

  • Jason W Bohland, Ph.D. · 412-383-3416 · j.bohland@pitt.edu
  • Alexander Ocampo, B.A. · amo104@pitt.edu
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Imaging Speech in Neurotypical Adults and Individuals With… (NCT06458153) | Bored Studies