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Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity

University of Texas Southwestern Medical Center · NCT05147909

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–80 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
124
US sites recruiting
1
Study start
September 14, 2022
Record last updated
February 17, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.

Being studied: Sodium Phosphate; Sodium Chloride

Conditions: Physical Inactivity; Phosphate Overload; Visceral Obesity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

The randomized crossover trial will be performed in on otherwise healthy subjects without diabetes mellitus, chronic kidney disease (CKD), preexisting cardiovascular disease or treatment with any vasoactive agent that might alter cardiovascular responses to exercise.

Exclusion Criteria

  • history of cardiopulmonary disease or chronic kidney disease,
  • treatment with antihypertensive medications,
  • estimated glomerular filtration rate (eGFR) \< 60 mL/min/1.73m2, (4) diabetes mellitus or other systemic illness,

(5) pregnancy, (6) hypersensitivity to sodium phosphate, (7) any history of substance abuse or current cigarette use, (8) any history of psychiatric illness, (9) history of active malignancy, (10) serum phosphorus \< 2.4 or > 4.5 mg/dL.

Recruiting US locations

  • University of Texas Southwestern

    Dallas, TX 75209

    Site contact: John Giacona, PA-C

Study contacts (from the official record)

  • John Giacona, PA-C · 2146484403 · john.giacona@utsouthwestern.edu
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Impact of Dietary Phosphate Excess on Exercise Capacity and… (NCT05147909) | Bored Studies