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Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease

Massachusetts General Hospital · NCT05904132

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 50–80 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
70
US sites recruiting
1
Study start
January 31, 2025
Record last updated
July 14, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tACS) to study patients with symptoms of mild cognitive impairment which is likely due to Alzheimer's disease or another form of dementia (AD-MCI). Patients will undergo an EEG and complete some questionnaires and computer tasks during each study visit. The project has the following aims and hypotheses: 1.) To determine the impact of closed-loop 40 Hz tACS on the entrainment of natural gamma rhythms in patients with AD-MCI, 2.) To determine the impact of closed-loop 40 Hz tACS on cognitive performance in patients with AD-MCI, and 3.) To assess the relationship between baseline neurodegenerative burden and impact of tACS. [exploratory]

Being studied: tACS device

Conditions: Alzheimer Disease; Mild Cognitive Impairment

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Overall cognitive functional status consistent with amnesic MCI (CDR 0.5) likely due to AD (AD biomarker supported)
  • 50-80 years of age
  • English native speakers

Exclusion Criteria

  • Known presence of a structural brain lesion (e.g., tumor, cortical infarct)
  • Acute or decompensated active medical conditions, including cancer, cardiovascular disease, stroke, congestive heart failure
  • Active hematological, renal, pulmonary, endocrine or hepatic disorders
  • Longstanding premorbid history (i.e., longer than 10 years) of alcohol or substance abuse with continuous abuse up to and including the time that the symptoms leading to clinical presentation developed
  • tACS contraindications (lesions in the scalp, history of seizures)

Recruiting US locations

  • Massachusetts General Hospital

    Charlestown, MA 02129

    Site contact: Joan Camprodon, MD, MPH, PhD

Study contacts (from the official record)

  • DNN Inbox · 6177265348 · mghdnn@mgh.harvard.edu
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Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease (NCT05904132) | Bored Studies