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RecruitingAccepts healthy volunteersEarly Phase 1

Insulin Regulation of Lipolysis and Lipolysis Proteins

Mayo Clinic · with National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT03866408

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–55 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
64
US sites recruiting
1
Study start
November 12, 2018
Record last updated
January 28, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which pioglitazone, a medication used to treat type 2 diabetes and improve insulin resistance, improves insulin-regulation of adipocyte fatty acid metabolism.

Being studied: Immediate weight loss; Pioglitazone; Deferred weight loss; Placebo

Conditions: Obesity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Men and Women between the ages of 18 and 55.
  • Women will be premenopausal
  • Non obese adults BMI between 18-25
  • Obese BMI 30-38

Exclusion Criteria, Pioglitazone package insert of contraindications for use:

  • Initiation in patients with established New York Heart Associations (NYHA) class III or IV Heart failure.
  • Use in patients with known hypersensitivity to pioglitazone or any other component of ACTOSE.

Recruiting US locations

  • Mayo Clinic in Rochester

    Rochester, MN 55905

    Site contact: Pamela A Reich · 507-255-6062 · reich.pamela@mayo.edu

All weight loss studies in Minnesota →
Insulin Regulation of Lipolysis and Lipolysis Proteins (NCT03866408) | Bored Studies