Weight loss · Minnesota
Weight loss and obesity studies in Minnesota
24 studies have at least one recruiting site in Minnesota. Weight-management research includes trials of new medicines, devices, diets and lifestyle programs for people with overweight or obesity, and studies of weight-related conditions such as fatty liver disease.
24 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1/Phase 2
First-in-human Study of the Safety, Tolerability, Pharmacokinetics, and Food Effect of ACCG-2671
Aconcagua Bio, Inc. a wholly owned subsidiary of Structure Therapeutics
- Location
- Dilworth, MN + 2 other US sites
- Eligibility basics
- Ages 25–75
- RecruitingHealthy volunteersEarly Phase 1
Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersOvernight stay mentioned
Circadian Rhythms in Human Adipose
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Regional Lipolysis Insulin Regulation
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Insulin Regulation of Lipolysis and Lipolysis Proteins
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 3
A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
- Location
- Mankato, MN + 55 other US sites
- Eligibility basics
- Ages 18–79
- Recruiting
The RESET System Pivotal Clinical Trial (Protocol Revision K)
Morphic Medical Inc.
- Location
- Rochester, MN + 25 other US sites
- Eligibility basics
- Ages 22–65
- Recruiting
Randomized Study on Transoral Outlet Reduction and Lifestyle Changes for Weight Regain After Gastric Bypass
Boston Scientific Corporation
- Location
- Rochester, MN + 8 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
Hoffmann-La Roche
- Location
- Minneapolis, MN + 43 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Use a Breathing Machine (PAP) (VESPER-OSA 1)
Pfizer
- Location
- Maplewood, MN + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Amgen
- Location
- Maplewood, MN + 136 other US sites
- Eligibility basics
- Ages 45–99
- RecruitingPhase 3
A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight
Eli Lilly and Company
- Location
- Maplewood, MN + 22 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity
Eli Lilly and Company
- Location
- Maplewood, MN + 68 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
Novo Nordisk A/S
- Location
- Minneapolis, MN + 26 other US sites
- Eligibility basics
- Ages 8–18
- RecruitingPhase 3
AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
Novo Nordisk A/S
- Location
- Minneapolis, MN + 13 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Amgen
- Location
- Mankato, MN + 117 other US sites
- Eligibility basics
- Ages 18–99
- RecruitingPhase 2
A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
Corxel Pharmaceuticals
- Location
- Edina, MN + 32 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 3
Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
- Location
- Mankato, MN + 12 other US sites
- Eligibility basics
- Ages 18–79
- RecruitingPhase 4
A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With Obesity
Gila Therapeutics, Inc.
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)
Rhythm Pharmaceuticals, Inc.
- Location
- Saint Paul, MN + 7 other US sites
- Eligibility basics
- Ages 4+
- RecruitingHealthy volunteers
Weight Loss Through Mayo Clinic Diet
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteers
Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteers
Breastmilk in Response to a Bout of Exercise
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–45 · Women only
- RecruitingHealthy volunteers
Family, Responsibility, Education, Support, and Health for Food Responsiveness
University of California, San Diego
- Location
- Minneapolis, MN + 1 other US site
- Eligibility basics
- Ages 7–12
Who these studies look for
Most of these studies set a BMI range and may exclude people taking certain weight-loss medicines or who have had bariatric surgery. Some require a weight-related condition such as type 2 diabetes or high blood pressure.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Can I join a weight loss study if I already take a GLP-1 medicine?
It depends on the study. Many exclude people currently or recently on weight-loss medicines; others are designed specifically for them. The listing’s eligibility criteria and the study team are the only reliable answer.