Phase 1 · Minnesota
Phase 1 clinical trials in Minnesota
61 studies have at least one recruiting site in Minnesota. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
61 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
A Study to Learn How the Body Processes the Study Medicine PF-07328948 in People With Reduced Kidney Function
Pfizer
- Location
- Saint Paul, MN + 3 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1/Phase 2
Harmony-HHT: ATV-1601 in Participants With Hereditary Hemorrhagic Telangiectasia (HHT)
Atavistik Bio, Inc
- Location
- Rochester, MN + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
First-in-human Study of the Safety, Tolerability, Pharmacokinetics, and Food Effect of ACCG-2671
Aconcagua Bio, Inc. a wholly owned subsidiary of Structure Therapeutics
- Location
- Dilworth, MN + 2 other US sites
- Eligibility basics
- Ages 25–75
- RecruitingHealthy volunteersPhase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of…
AstraZeneca
- Location
- Saint Paul, MN + 3 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
A Study of JPH034 in Healthy Adult Participants
J-Pharma Co., Ltd.
- Location
- Dilworth, MN
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1
Safety, Tolerability, and Pharmacokinetics of ASCT-83 in Healthy Adults
Alcamena Stem Cell Therapeutics
- Location
- Saint Paul, MN
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 1
A Study of Mirikizumab Solution (LY3074828) in Healthy Participants
Eli Lilly and Company
- Location
- Dilworth, MN + 4 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Optimizing Transcranial Magnetic Stimulation for Stimulant Use Disorder
University of Minnesota
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
JIT: Effect of Pain on DT in TMD
University of Minnesota
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteersEarly Phase 1
Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Microelectrode Recordings From the Vagus Nerve in Awake Humans
University of Minnesota
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 18–40
- RecruitingHealthy volunteersEarly Phase 1
A Study of Niacin Regulation
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Regional Lipolysis Insulin Regulation
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Stimulating After Recovery From Traumatic Brain Injury
University of Minnesota
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Dietary and Topical Magnesium Replacement or Supplementation in Patients With Lymphoma
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Insulin Regulation of Lipolysis and Lipolysis Proteins
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Trigeminal Evoked Responses to Improve Rhizotomy
University of Minnesota
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Encoded Therapeutics
- Location
- Rochester, MN + 9 other US sites
- Eligibility basics
- Ages 6 mo–17
- RecruitingPhase 1/Phase 2
Safety and Preliminary Efficacy of CTX112 in Adult Participants With Relapsed/Refractory Hematologic Autoimmune Disease
CRISPR Therapeutics AG
- Location
- Rochester, MN + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
RESET-MG: A Study to Evaluate the Safety and Efficacy of CABA-201 in Participants With Generalized Myasthenia Gravis
Cabaletta Bio
- Location
- Rochester, MN + 16 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
Phase 1/2 Study of ABO-101 in Primary Hyperoxaluria Type 1 (redePHine)
Arbor Biotechnologies
- Location
- Rochester, MN
- Eligibility basics
- Ages 6–64
- RecruitingPhase 1
A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)
Merck Sharp & Dohme LLC
- Location
- Minneapolis, MN + 20 other US sites
- Eligibility basics
- Up to age 17
- RecruitingPhase 1
Safety, Tolerability and Pharmacokinetics of AZD1613 in Adults With Autosomal Dominant Polycystic Kidney Disease
AstraZeneca
- Location
- Rochester, MN + 4 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Study of Pirtobrutinib in Participants With Immune Thrombocytopenia
Eli Lilly and Company
- Location
- Rochester, MN + 7 other US sites
- Eligibility basics
- Ages 18+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.