Phase 1 · Iowa
Phase 1 clinical trials in Iowa
25 studies have at least one recruiting site in Iowa. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
25 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
A Research Study Looking at How Different Doses of Study Medicine (Inno8) Work in the Body of People With Haemophilia A
Novo Nordisk A/S
- Location
- Iowa City, IA + 4 other US sites
- Eligibility basics
- Ages 18–64 · Men only
- RecruitingHealthy volunteersPhase 1/Phase 2
Chronic Lung Allograft Dysfunction MRI Study
Sean Fain
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersEarly Phase 1
Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes
Anna Stanhewicz, PhD
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–50 · Women only
- RecruitingHealthy volunteersEarly Phase 1
Role of ET-1, Physical Activity, and Sedentary Behavior in Microvascular Dysfunction Following GDM
Anna Stanhewicz, PhD
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–50 · Women only
- RecruitingHealthy volunteersEarly Phase 1
Antidepressant Therapy for Improved Blood Vessel Health After Preeclampsia
Anna Stanhewicz, PhD
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–45 · Women only
- RecruitingHealthy volunteersEarly Phase 1
Vascular Effects of High-Salt After Preeclampsia
Anna Stanhewicz, PhD
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–45 · Women only
- RecruitingHealthy volunteersPhase 1
The Impact of Gestational Diabetes Mellitus on Cerebral Blood Flow and Cerebrovascular Function After Pregnancy
Anna Stanhewicz, PhD
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–50 · Women only
- RecruitingHealthy volunteersEarly Phase 1
Sex Differences in the Vascular Effects of E-cigarette Use
Anna Stanhewicz, PhD
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–24
- RecruitingHealthy volunteersEarly Phase 1
Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use
University of Iowa
- Location
- Iowa City, IA + 1 other US site
- Eligibility basics
- Ages 18–24
- RecruitingHealthy volunteersEarly Phase 1
Sensitivity of Angiotensin II Type II Receptors in Women Following Preeclampsia
Anna Stanhewicz, PhD
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–45 · Women only
- RecruitingHealthy volunteersEarly Phase 1
Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation
University of Iowa
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–30
- RecruitingHealthy volunteersEarly Phase 1
Prenatal Aspirin and Postpartum Vascular Function
Anna Stanhewicz, PhD
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–50 · Women only
- RecruitingHealthy volunteersEarly Phase 1
Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes
Anna Stanhewicz, PhD
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–45 · Women only
- RecruitingPhase 1
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
CRISPR Therapeutics
- Location
- Iowa City, IA + 7 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus
Cullinan Therapeutics Inc.
- Location
- Iowa City, IA + 10 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
AstraZeneca
- Location
- Iowa City, IA + 2 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With…
Cabaletta Bio
- Location
- Iowa City, IA + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Persons With Severe or Moderate Hemophilia A
Hoffmann-La Roche
- Location
- Iowa City, IA + 2 other US sites
- Eligibility basics
- Ages 2–59 · Men only
- RecruitingPhase 1
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of GIGA-2339 in Participants With Chronic Hepatitis B Virus Infection
GigaGen, Inc.
- Location
- Iowa City, IA + 10 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Study of Circular RNA Treatment in Patients With Radiation Induced Xerostomia-1
RiboX Therapeutics Ltd.
- Location
- Iowa City, IA + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease
Allogene Therapeutics
- Location
- Iowa City, IA + 15 other US sites
- Eligibility basics
- Ages 18–74
- RecruitingPhase 1/Phase 2
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
Sanofi Pasteur, a Sanofi Company
- Location
- Ames, IA + 78 other US sites
- Eligibility basics
- Ages 18–45
- RecruitingPhase 1/Phase 2
Study of ATX-01 in Participants With DM1
ARTHEx Biotech S.L.
- Location
- Iowa City, IA + 4 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingPhase 1/Phase 2
A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)
Neurona Therapeutics
- Location
- Iowa City, IA + 15 other US sites
- Eligibility basics
- Ages 18–75
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.