Phase 1 · Missouri
Phase 1 clinical trials in Missouri
54 studies have at least one recruiting site in Missouri. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
54 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
A Study of V132 in Healthy Older Participants (V132-001)
Merck Sharp & Dohme LLC
- Location
- Springfield, MO + 9 other US sites
- Eligibility basics
- Ages 50–75
- RecruitingHealthy volunteersPhase 1
A Clinical Trial of MK-1406 in Healthy Participants (MK-1406-008)
Merck Sharp & Dohme LLC
- Location
- Springfield, MO + 5 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 1
Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HTX-001
Haya Therapeutics, Inc.
- Location
- Kansas City, MO + 1 other US site
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1
A Clinical Study of Novel Pneumococcal Vaccine V118C in Children (V118C-002)
Merck Sharp & Dohme LLC
- Location
- St Louis, MO + 14 other US sites
- Eligibility basics
- Ages 2 mo–1
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate Safety, Tolerability, and Immunogenicity of V350A and V350B in Healthy Participants (V350-001).
Merck Sharp & Dohme LLC
- Location
- Kansas City, MO + 5 other US sites
- Eligibility basics
- Ages 12–30
- RecruitingHealthy volunteersPhase 1
A Clinical Trial Investigating the Safety and Biological Activity of the Antibody BNT351 in Adults Living Without and With HIV
BioNTech SE
- Location
- St Louis, MO + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B or Factor VII…
Equilibra Bioscience LLC
- Location
- St Louis, MO + 6 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
Safety and Immunogenicity Study of Revaccination With SCB-1019T in Healthy Adults
Clover Biopharmaceuticals USA, LLC
- Location
- Kansas City, MO + 4 other US sites
- Eligibility basics
- Ages 60–85
- RecruitingHealthy volunteersPhase 1
A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- St Louis, MO + 4 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 1
Effects of Sirolimus on Asymptomatic ApoE4 Carriers
University of Missouri-Columbia
- Location
- Columbia, MO
- Eligibility basics
- Ages 45–65 · Women only
- RecruitingHealthy volunteersEarly Phase 1
Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
University of Missouri-Columbia
- Location
- Columbia, MO
- Eligibility basics
- Ages 18–70 · Women only
- RecruitingHealthy volunteersEarly Phase 1
Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women
University of Missouri-Columbia
- Location
- Columbia, MO
- Eligibility basics
- Ages 18–70 · Women only
- RecruitingHealthy volunteersEarly Phase 1
PET Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With 64Cu-NODAGA-CANF (Volunteer - Dosimetry Study)
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Light Therapy for Obsessive-compulsive Disorder (OCD)
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 17–35
- RecruitingHealthy volunteersEarly Phase 1
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
University of Missouri-Columbia
- Location
- Columbia, MO
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 1
Liver Adiposity Effects on Pediatric Statin
Children's Mercy Hospital Kansas City
- Location
- Kansas City, MO
- Eligibility basics
- Ages 8–21
- RecruitingHealthy volunteersEarly Phase 1
PET Imaging CCR2 in Lung Inflammation
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 1
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503
University of Pennsylvania
- Location
- St Louis, MO + 2 other US sites
- Eligibility basics
- Ages 40–85
- RecruitingHealthy volunteersEarly Phase 1
PET Imaging of MMP Activation in AAA: Clinical Component
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Early Neurovascular Adaptations in Aging Women
University of Missouri-Columbia
- Location
- Columbia, MO
- Eligibility basics
- Ages 18–70 · Women only
- RecruitingHealthy volunteersEarly Phase 1
Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms
University of Missouri-Columbia
- Location
- Columbia, MO
- Eligibility basics
- Ages 18–70 · Women only
- RecruitingHealthy volunteersPhase 1
PET Detection of CCR2 in Human Atherosclerosis
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 18–89
- RecruitingPhase 1
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
CRISPR Therapeutics
- Location
- St Louis, MO + 7 other US sites
- Eligibility basics
- Ages 18–70
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.