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RecruitingAccepts healthy volunteersEarly Phase 1

PET Imaging CCR2 in Lung Inflammation

Washington University School of Medicine · with National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) · NCT03492762

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
110
US sites recruiting
1
Study start
February 27, 2018
Record last updated
May 1, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The primary objective of this study is to assess the lung distribution of the Positron Emission Tomography (PET) imaging radiotracer Cu-DOTA-ECL1i, which binds to the specific population inflammatory cells, in patients with fibrotic lung diseases. This objective includes sub-studies to assess radiotracer distribution in the lung, the reproducibility of PET scans and the relationship of the scan to distribution of inflammatory cells in human lung tissue. The overall goal is to assess the potential of the radiotracer to track inflammatory cells in lung diseases.

Being studied: Cu-DOTA-ECL1i

Conditions: Lung Inflammation

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Men or women 21 years of age or older who have never smoked or current smokers who smoked at least 10 cigarettes per day (1/2 pack) and have smoked at least 100 cigarettes (5 packs) over the past month.
  • Screening FEV1 and FVC > 80% of predicted
  • Capable of lying still and supine within the PET/CT and PET/MR scanner for \~1 hour and follow instructions for breathing protocol during the CT portion
  • No illicit drug use or other inhaled drug use (including pharmacologic agents, recreational agents, or illicit drugs) within the past year
  • No known history of cardiac, pulmonary, hepatic or renal disease or diabetes
  • No history of claustrophobia or other preventing condition that has previously or would interfere with completion of protocol specified imaging sessions
  • Able to comprehend and willing to follow instructions for the study procedures as called for by the protocol
  • BMI ≤ 35

Exclusion Criteria

  • Currently enrolled in another study using an investigational drug
  • Pregnancy (confirmed by urine pregnancy test)
  • Active symptoms or history of cardiac, pulmonary, hepatic or renal disease or diabetes
  • Currently taking any prescription medications
  • Presence of an implanted device that is incompatible with CT or MRI scanning
  • Creatinine > 1.30 mg/dL, AST > 50 Units/L, ALT > 55 Units/L, or total bilirubin > 1.2 mg/dL

Recruiting US locations

  • Washington University School of Medicine

    St Louis, MO 63110

    Site contact: Steven Brody, MD · 314-362-8969 · brodys@wustl.edu

Study contacts (from the official record)

  • Steven Brody, MD · 314-362-8969 · brodys@wustl.edu
All healthy volunteers studies in Missouri →
PET Imaging CCR2 in Lung Inflammation (NCT03492762) | Bored Studies