Phase 1 · Kentucky
Phase 1 clinical trials in Kentucky
22 studies have at least one recruiting site in Kentucky. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
22 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
A Clinical Study of Novel Pneumococcal Vaccine V118C in Children (V118C-002)
Merck Sharp & Dohme LLC
- Location
- Louisville, KY + 14 other US sites
- Eligibility basics
- Ages 2 mo–1
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis
Xencor, Inc.
- Location
- Louisville, KY + 27 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of GS-4321 in Healthy Participants and Participants With Chronic Hepatitis Delta Virus
Gilead Sciences
- Location
- Louisville, KY + 4 other US sites
- Eligibility basics
- Ages 18–69
- RecruitingHealthy volunteersPhase 1/Phase 2
A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
Novartis Pharmaceuticals
- Location
- Louisville, KY + 18 other US sites
- Eligibility basics
- Ages 18–100
- RecruitingHealthy volunteersPhase 1
A Study of BBT002 in Healthy Volunteers (HVs) and in Adult Patients With Chronic Obstructive Pulmonary Disease (COPD) or Chronic Rhiosininusitis With Nasal Polyps (CRSwNP)
Bambusa Therapeutics
- Location
- Bowling Green, KY + 1 other US site
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Safety and Immunogenicity Study of Revaccination With SCB-1019T in Healthy Adults
Clover Biopharmaceuticals USA, LLC
- Location
- Lexington, KY + 4 other US sites
- Eligibility basics
- Ages 60–85
- RecruitingHealthy volunteersEarly Phase 1
Repeated CBD Administration and Cannabis Outcomes
Hannah Harris
- Location
- Lexington, KY
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Cannabis and Opioid Use Disorder
Shanna Babalonis, PhD
- Location
- Lexington, KY
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Suvorexant and Alcohol
William Stoops
- Location
- Lexington, KY
- Eligibility basics
- Ages 21–55
- RecruitingHealthy volunteersEarly Phase 1
Cocaine and Pentoxifylline (BED IN 47)
William Stoops
- Location
- Lexington, KY
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Spinal Cord Injury Neuroprotection With Glyburide
Francis Farhadi
- Location
- Lexington, KY
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1/Phase 2
Peppermint Oil for the Treatment of Interstitial Cystitis / Bladder Pain Syndrome
University of Louisville
- Location
- Louisville, KY
- Eligibility basics
- Ages 18–65 · Women only
- RecruitingPhase 1/Phase 2
A Multicenter Study to Evaluate Safety, Tolerability, and Clinical Responses of DSP-1083 Into Subjects With Parkinson's Disease
Sumitomo Pharma America, Inc.
- Location
- Lexington, KY + 2 other US sites
- Eligibility basics
- Ages 40–72
- RecruitingPhase 1
Safety and Efficacy of Soquelitinib in Adults With Hidradenitis Suppurativa
Corvus Pharmaceuticals, Inc.
- Location
- Bowling Green, KY + 8 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Study to Evaluate the Maximal Use of Ruxolitinib Cream in Adult and Adolescent Participants With Hidradenitis Suppurativa
Incyte Corporation
- Location
- Bowling Green, KY + 15 other US sites
- Eligibility basics
- Ages 12–75
- RecruitingPhase 1
PT150 Drug for Use in Alcohol Use Disorder
Pop Test Oncology LLC
- Location
- Lexington, KY
- Eligibility basics
- Ages 21–55
- RecruitingPhase 1
A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease
Allogene Therapeutics
- Location
- Louisville, KY + 15 other US sites
- Eligibility basics
- Ages 18–74
- RecruitingPhase 1/Phase 2
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
Sanofi Pasteur, a Sanofi Company
- Location
- Bowling Green, KY + 78 other US sites
- Eligibility basics
- Ages 18–45
- RecruitingPhase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity
MBX Biosciences
- Location
- Lexington, KY + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
Fate Therapeutics
- Location
- Louisville, KY + 15 other US sites
- Eligibility basics
- Ages 12–70
- RecruitingPhase 1/Phase 2
Treatment of Moderate to Severe Refractory Crohn's Disease
Tr1X, Inc.
- Location
- Louisville, KY + 12 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
Amiodarone-Infused CardiaMend Patches for the Prevention of New-Onset POAF in Cardiac Surgery Subjects
Helios Cardio Inc.
- Location
- Louisville, KY
- Eligibility basics
- Ages 20–85
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.