Phase 1 · Ohio
Phase 1 clinical trials in Ohio
83 studies have at least one recruiting site in Ohio. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
83 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
A Single and Multiple Ascending Dose Study of HM17321 in Healthy and Obese Participants
Hanmi Pharmaceutical Company Limited
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
LH-001 vs Placebo in Healthy Participants
Chien-Liang Lin
- Location
- Columbus, OH
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1/Phase 2
A Study of BLB-201 RSV Vaccine in Infants and Children
Blue Lake Biotechnology Inc.
- Location
- Beachwood, OH + 13 other US sites
- Eligibility basics
- Ages 6 mo–5
- RecruitingHealthy volunteersPhase 1
A Study of V132 in Healthy Older Participants (V132-001)
Merck Sharp & Dohme LLC
- Location
- Columbus, OH + 9 other US sites
- Eligibility basics
- Ages 50–75
- RecruitingHealthy volunteersPhase 1
A Clinical Trial of MK-1406 in Healthy Participants (MK-1406-008)
Merck Sharp & Dohme LLC
- Location
- Cleveland, OH + 5 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 1/Phase 2
Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older
Sanofi
- Location
- Beachwood, OH + 49 other US sites
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis
Xencor, Inc.
- Location
- Beavercreek, OH + 27 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate Safety, Tolerability, and Immunogenicity of V350A and V350B in Healthy Participants (V350-001).
Merck Sharp & Dohme LLC
- Location
- Columbus, OH + 5 other US sites
- Eligibility basics
- Ages 12–30
- RecruitingHealthy volunteersPhase 1
A Study of GSK4527363 in Healthy Participants, Systemic Lupus Erythematosus (SLE) Participants, Healthy Chinese, and Japanese Participants and CTD-ILD Participants
GlaxoSmithKline
- Location
- Columbus, OH + 2 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study to Learn About a Vaccine Against E Coli in Healthy Adults
Pfizer
- Location
- Cincinnati, OH + 9 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 1
A 3-part Study of SYX-5219 in Healthy Volunteers and Participants With Atopic Dermatitis
Sitryx Therapeutics Ltd
- Location
- Boardman, OH + 5 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Single- and Multiple-Ascending Dose Study of SRK-439 in Healthy Adults
Scholar Rock, Inc.
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
First in Human Dose Escalation Study Evaluating the Safety and Immunogenicity of IVT's Shigella-04 Vaccine in Healthy Young Adults
Inventprise Inc.
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 18–49
- RecruitingHealthy volunteersEarly Phase 1
Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT
Sumithira Vasu
- Location
- Columbus, OH
- Eligibility basics
- Ages 1–85
- RecruitingHealthy volunteersEarly Phase 1
HA35 Acute Alcohol Study
The Cleveland Clinic
- Location
- Cleveland, OH
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteersPhase 1/Phase 2
Assessing Pulmonary Changes in HSCT
Children's Hospital Medical Center, Cincinnati
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 3+
- RecruitingHealthy volunteersPhase 1/Phase 2
Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration
Children's Hospital Medical Center, Cincinnati
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
BZLF1 Peptide Vaccine (OSU-2131) With QS-21 for the Prevention of Epstein-Barr Virus Related Cancer in Patients Awaiting Solid Organ Transplants
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
Nationwide Children's Hospital
- Location
- Cincinnati, OH + 1 other US site
- Eligibility basics
- Ages 1–21
- RecruitingHealthy volunteersPhase 1
Comparative Evaluation of Nicotine Analogs
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersEarly Phase 1
Impulsivity Domains and Subjective Response
Jessica Weafer
- Location
- Columbus, OH + 1 other US site
- Eligibility basics
- Ages 21–25
- RecruitingHealthy volunteersPhase 1
Comparative Analysis of Biotinylated, Irradiated and 51-Chromium Radiolabeled Red Blood Cells for Analysis of Recovery and Survival After Autologous Transfusion
Jose Cancelas
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults
Children's Hospital Medical Center, Cincinnati
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 6+
- RecruitingHealthy volunteersEarly Phase 1
Effect of C-peptide on Hypoglycemic Counterregulation
University of Cincinnati
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 18–40
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.