Phase 1 · Columbus area, OH
Phase 1 clinical trials in Columbus area, OH
32 recruiting studies have a site in the Columbus area. This page includes nearby cities such as Dublin, Westerville, Hilliard, Gahanna.
32 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
LH-001 vs Placebo in Healthy Participants
Chien-Liang Lin
- Location
- Columbus, OH
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A Study of V132 in Healthy Older Participants (V132-001)
Merck Sharp & Dohme LLC
- Location
- Columbus, OH + 9 other US sites
- Eligibility basics
- Ages 50–75
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate Safety, Tolerability, and Immunogenicity of V350A and V350B in Healthy Participants (V350-001).
Merck Sharp & Dohme LLC
- Location
- Columbus, OH + 5 other US sites
- Eligibility basics
- Ages 12–30
- RecruitingHealthy volunteersPhase 1
A Study of GSK4527363 in Healthy Participants, Systemic Lupus Erythematosus (SLE) Participants, Healthy Chinese, and Japanese Participants and CTD-ILD Participants
GlaxoSmithKline
- Location
- Columbus, OH + 2 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT
Sumithira Vasu
- Location
- Columbus, OH
- Eligibility basics
- Ages 1–85
- RecruitingHealthy volunteersPhase 1
BZLF1 Peptide Vaccine (OSU-2131) With QS-21 for the Prevention of Epstein-Barr Virus Related Cancer in Patients Awaiting Solid Organ Transplants
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
Nationwide Children's Hospital
- Location
- Cincinnati, OH + 1 other US site
- Eligibility basics
- Ages 1–21
- RecruitingHealthy volunteersPhase 1
Comparative Evaluation of Nicotine Analogs
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersEarly Phase 1
Impulsivity Domains and Subjective Response
Jessica Weafer
- Location
- Columbus, OH + 1 other US site
- Eligibility basics
- Ages 21–25
- RecruitingPhase 1/Phase 2
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Encoded Therapeutics
- Location
- Columbus, OH + 9 other US sites
- Eligibility basics
- Ages 6 mo–17
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B
Regeneron Pharmaceuticals
- Location
- Columbus, OH + 16 other US sites
- Eligibility basics
- Ages 2+ · Men only
- RecruitingPhase 1/Phase 2
A Study to Evaluate Topical ATR04-484 for EGFRi-Associated Dermal Toxicity
Azitra Inc.
- Location
- Gahanna, OH + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy
Hoffmann-La Roche
- Location
- Columbus, OH + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Phase 1 Study of LY5830966 in Participants With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I…
Ajax Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company
- Location
- Cincinnati, OH + 12 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Sumitomo Pharma America, Inc.
- Location
- Columbus, OH + 29 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease
Merida Biosciences
- Location
- Columbus, OH + 10 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Study of SGT-212 Gene Therapy in Friedreich's Ataxia
Solid Biosciences Inc.
- Location
- Columbus, OH + 2 other US sites
- Eligibility basics
- Ages 18–40
- RecruitingPhase 1
A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)
Insmed Gene Therapy LLC
- Location
- Columbus, OH + 6 other US sites
- Eligibility basics
- Ages 18–79
- RecruitingPhase 1
Study of GS-0415 and How It Works in People With HIV
Gilead Sciences
- Location
- Cincinnati, OH + 14 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
HCW9302 (Interleukin-2 Fusion Protein) for Alopecia Areata
HCW Biologics
- Location
- Columbus, OH + 2 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders
TG Therapeutics, Inc.
- Location
- Cleveland, OH + 7 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Dose Escalation Study of EG110A, Administered by Intradetrusor Injections to Adults With Neurogenic Detrusor Overactivity-related Incontinence Following Spinal Cord Injury Who Regularly Perform Clean Intermittent…
Cyllene Therapeutics
- Location
- Columbus, OH + 3 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
UniQure Biopharma B.V.
- Location
- Cleveland, OH + 15 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
A Study of Amicidin-β Topical Solution for Patients With Surgical or Traumatic Wound Infections
Macro Biologics, Inc.
- Location
- Columbus, OH + 4 other US sites
- Eligibility basics
- Ages 18–79
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.