Phase 1 · Illinois
Phase 1 clinical trials in Illinois
69 studies have at least one recruiting site in Illinois. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
69 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1/Phase 2
Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older
Sanofi
- Location
- Melrose Park, IL + 49 other US sites
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteersPhase 1
A Study to Assess Safety, Tolerability, and How Single and Multiple Injections or Infusions of ABBV-313 Affects the Body of Adult Participants
AbbVie
- Location
- Grayslake, IL + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate the Safety and Pharmacokinetics of Multiple Doses Upadacitinib, Tofacitinib, and Baricitinib in Healthy Adult Volunteers
AbbVie
- Location
- Grayslake, IL
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants
AbbVie
- Location
- Grayslake, IL + 3 other US sites
- Eligibility basics
- Ages 65–85
- RecruitingHealthy volunteersPhase 1/Phase 2
Study to Assess Safety and Immunogenicity of an Egg-based H5N8 Influenza Vaccine at Multiple Dose Levels Adjuvanted With Matrix-M in Healthy Participants 18 Years of Age and Above.
Sanofi
- Location
- Oak Brook, IL + 15 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
A Clinical Trial Investigating the Safety and Biological Activity of the Antibody BNT351 in Adults Living Without and With HIV
BioNTech SE
- Location
- Chicago, IL + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of BCX17725
BioCryst Pharmaceuticals
- Location
- Chicago, IL + 4 other US sites
- Eligibility basics
- Ages 12–65
- RecruitingHealthy volunteersPhase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of…
AstraZeneca
- Location
- Chicago, IL + 3 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
A Study to Assess the Safety, Tolerability and How Single Ascending Doses of ABBV-859 Moves Through the Body of Healthy Adult Participants
AbbVie
- Location
- Grayslake, IL + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B or Factor VII…
Equilibra Bioscience LLC
- Location
- Chicago, IL + 6 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Single Ascending Doses of ABBV-1451 Infusions and Injections in Healthy Adult Participants
AbbVie
- Location
- Grayslake, IL
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of ABBV-243 in Healthy Adults.
AbbVie
- Location
- Grayslake, IL
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersEarly Phase 1
Sleep, Dreaming, and Virtual Reality for Mental Health
Northwestern University
- Location
- Evanston, IL + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Effect of Neural Constraints on Movement in Stroke
Northwestern University
- Location
- Chicago, IL
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Ivosidenib and Ruxolitinib in Patients With Advanced Myeloproliferative Neoplasms (MPNs) That Have an IDH1 Gene Mutation
University of Chicago
- Location
- Chicago, IL + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
Aging and Task-specific Training to Reduce Falls
University of Illinois at Chicago
- Location
- Chicago, IL
- Eligibility basics
- Ages 60–90
- RecruitingHealthy volunteersEarly Phase 1
rhPSMA-73 PET-MRI Imaging for the Detection of Prostate Cancer Among Men Who Are Otherwise Candidates for Active Surveillance
Northwestern University
- Location
- Chicago, IL
- Eligibility basics
- Ages 18+ · Men only
- RecruitingHealthy volunteersPhase 1/Phase 2
Behavioral Economic Attributes of Recreation
Rush University Medical Center
- Location
- Chicago, IL
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Study of KM-023 in Healthy Volunteers and Patients With Olmsted Syndrome.
Orvida Pharma (formerly Kamari Pharma)
- Location
- Chicago, IL
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1/Phase 2
Dex +/- Caffeine Sedation in a Post-MRI Recovery in a Pediatric Population
University of Chicago
- Location
- Chicago, IL
- Eligibility basics
- Ages 3–12
- RecruitingHealthy volunteersEarly Phase 1
R01.Aim 2.Study 1: IsoReach
Shirley Ryan AbilityLab
- Location
- Chicago, IL
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Encoded Therapeutics
- Location
- Chicago, IL + 9 other US sites
- Eligibility basics
- Ages 6 mo–17
- RecruitingPhase 1
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
CRISPR Therapeutics
- Location
- Chicago, IL + 7 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Sanofi
- Location
- Lemont, IL + 30 other US sites
- Eligibility basics
- Ages 60+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.